di-N-(L-1-ethoxycarbonylethylamino)[3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy]methylphosphonamide

Base Information

Chemical Name:di-N-(L-1-ethoxycarbonylethylamino)[3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy]methylphosphonamide
CAS No.:852948-39-1
Molecular Formula:C₂₉H₄₃N₂O₇P
Molecular Weight:562.643
Hs Code.:

Synonyms:di-N-(L-1-ethoxycarbonylethylamino)[3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy]methylphosphonamide

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Chemical Property of di-N-(L-1-ethoxycarbonylethylamino)[3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy]methylphosphonamide

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Technology Process of di-N-(L-1-ethoxycarbonylethylamino)[3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy]methylphosphonamide

There total 10 articles about di-N-(L-1-ethoxycarbonylethylamino)[3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy]methylphosphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3082-75-5
L-Alanine ethyl ester

: C₁₉H₂₃Cl₂O₃P

: 852948-39-1
di-N-(L-1-ethoxycarbonylethylamino)[3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy]methylphosphonamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 14h;

Reference yield:

: 7463-51-6
4-bromo-3,5-dimethylphenol

: 852948-39-1
di-N-(L-1-ethoxycarbonylethylamino)[3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy]methylphosphonamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: 1H-imidazole / dichloromethane / 2.67 h / 10 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; water / 4 h / -73 - -70 °C

2.2: 1.08 h / -73 - -70 °C

3.1: n-butyllithium / tetrahydrofuran / 1.75 h / -75 - -70 °C

3.2: 3 h / -75 - -70 °C

4.1: hydrogen / palladium 10% on activated carbon / acetic acid; ethyl acetate / 3 h / 20 °C

5.1: tetraethylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

5.2: 0.25 h

6.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

6.2: 16 h / 0 - 20 °C

7.1: trimethylsilyl bromide / dichloromethane / 16 h / 0 - 20 °C

8.1: water / acetonitrile / 16 h / 0 - 20 °C

9.1: oxalyl dichloride / N,N-dimethyl-formamide / 1,2-dimethoxyethane / 3 h / 20 - 50 °C

10.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 0 - 20 °C

With 1H-imidazole; n-butyllithium; oxalyl dichloride; trimethylsilyl bromide; water; hydrogen; sodium hydride; tetraethylammonium fluoride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 328236-43-7
(4-bromo-3,5-dimethylphenoxy)triisopropylsilane

: 852948-39-1
di-N-(L-1-ethoxycarbonylethylamino)[3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy]methylphosphonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran; water / 4 h / -73 - -70 °C

1.2: 1.08 h / -73 - -70 °C

2.1: n-butyllithium / tetrahydrofuran / 1.75 h / -75 - -70 °C

2.2: 3 h / -75 - -70 °C

3.1: hydrogen / palladium 10% on activated carbon / acetic acid; ethyl acetate / 3 h / 20 °C

4.1: tetraethylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

4.2: 0.25 h

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

5.2: 16 h / 0 - 20 °C

6.1: trimethylsilyl bromide / dichloromethane / 0.25 h / -30 °C

7.1: oxalyl dichloride / N,N-dimethyl-formamide / 1,2-dimethoxyethane / 3 h / 20 - 50 °C

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 0 - 20 °C

With n-butyllithium; oxalyl dichloride; trimethylsilyl bromide; hydrogen; sodium hydride; tetraethylammonium fluoride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;