4-<4-(benzyloxy)butyl>-4aα-methyl-3,4,4a,7,8,9aα-hexahydro-9H-benzocycloheptene-2(1H),5(6H)-dione

Base Information

Chemical Name:4-<4-(benzyloxy)butyl>-4aα-methyl-3,4,4a,7,8,9aα-hexahydro-9H-benzocycloheptene-2(1H),5(6H)-dione
CAS No.:79391-95-0
Molecular Formula:C₂₃H₃₂O₃
Molecular Weight:356.505
Hs Code.:

Synonyms:4-<4-(benzyloxy)butyl>-4aα-methyl-3,4,4a,7,8,9aα-hexahydro-9H-benzocycloheptene-2(1H),5(6H)-dione

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Chemical Property of 4-<4-(benzyloxy)butyl>-4aα-methyl-3,4,4a,7,8,9aα-hexahydro-9H-benzocycloheptene-2(1H),5(6H)-dione

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Technology Process of 4-<4-(benzyloxy)butyl>-4aα-methyl-3,4,4a,7,8,9aα-hexahydro-9H-benzocycloheptene-2(1H),5(6H)-dione

There total 1 articles about 4-<4-(benzyloxy)butyl>-4aα-methyl-3,4,4a,7,8,9aα-hexahydro-9H-benzocycloheptene-2(1H),5(6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: (4-Benzyloxy)butylmagnesium bromide

: 79391-94-9
(4aR,9aR)-4a-Methyl-4a,6,7,8,9,9a-hexahydro-1H-benzocycloheptene-2,5-dione

: 79391-95-0
4-<4-(benzyloxy)butyl>-4aα-methyl-3,4,4a,7,8,9aα-hexahydro-9H-benzocycloheptene-2(1H),5(6H)-dione

Guidance literature:: With copper diacetate; In tetrahydrofuran; 1) -30 deg C to RT, 2) RT, 2.5 h;
DOI:10.1021/jo00337a008

Reference yield:

: 79391-95-0
4-<4-(benzyloxy)butyl>-4aα-methyl-3,4,4a,7,8,9aα-hexahydro-9H-benzocycloheptene-2(1H),5(6H)-dione

: 79391-97-2
C₂₉H₄₇N₂O₅P

Guidance literature:: Multi-step reaction with 2 steps

1: p-TsOH*H₂O / benzene / 0.75 h / Heating

2: 1) LDA, 2) HMPA / 1) THF, 0 deg C, 30 min, 2a) to RT, 2b) RT, 1.5 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; toluene-4-sulfonic acid; lithium diisopropyl amide; In benzene;
DOI:10.1021/jo00337a008