[2-tert-butoxycarbonylamino-3,3-difluoro-2-(2-fluorophenyl)-propyl]cyanomethylcarbamic acid 2,2,2-trichloroethyl ester

Base Information

Chemical Name:[2-tert-butoxycarbonylamino-3,3-difluoro-2-(2-fluorophenyl)-propyl]cyanomethylcarbamic acid 2,2,2-trichloroethyl ester
CAS No.:1313526-17-8
Molecular Formula:C₁₉H₂₁Cl₃F₃N₃O₄
Molecular Weight:518.748
Hs Code.:

Synonyms:[2-tert-butoxycarbonylamino-3,3-difluoro-2-(2-fluorophenyl)-propyl]cyanomethylcarbamic acid 2,2,2-trichloroethyl ester

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Chemical Property of [2-tert-butoxycarbonylamino-3,3-difluoro-2-(2-fluorophenyl)-propyl]cyanomethylcarbamic acid 2,2,2-trichloroethyl ester

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Technology Process of [2-tert-butoxycarbonylamino-3,3-difluoro-2-(2-fluorophenyl)-propyl]cyanomethylcarbamic acid 2,2,2-trichloroethyl ester

There total 6 articles about [2-tert-butoxycarbonylamino-3,3-difluoro-2-(2-fluorophenyl)-propyl]cyanomethylcarbamic acid 2,2,2-trichloroethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 460-00-4
1-Bromo-4-fluorobenzene

: 1313526-17-8
[2-tert-butoxycarbonylamino-3,3-difluoro-2-(2-fluorophenyl)-propyl]cyanomethylcarbamic acid 2,2,2-trichloroethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2.5 h / -65 °C

1.2: -80 - -40 °C

2.1: toluene / 4 h / 105 °C / Industry scale

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 2 h / 25 °C

4.1: zinc; acetic acid / 2 h / 20 - 40 °C

5.1: hydrogen; sodium acetate / 5% Pd(II)/C(eggshell) / ethanol

6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 80 °C

7.1: sodium hydrogencarbonate / dichloromethane; water / 3.67 h / 25 - 26 °C / Cooling with ice

With n-butyllithium; hydrogen; sodium acetate; sodium hydrogencarbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropylamine; N-ethyl-N,N-diisopropylamine; zinc; 5% Pd(II)/C(eggshell); In tetrahydrofuran; ethanol; hexane; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1262858-97-8
1-(5-bromo-2-fluorophenyl)-2,2-difluoroethanone

: 1313526-17-8
[2-tert-butoxycarbonylamino-3,3-difluoro-2-(2-fluorophenyl)-propyl]cyanomethylcarbamic acid 2,2,2-trichloroethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: toluene / 4 h / 105 °C / Industry scale

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / 2 h / 25 °C

3: zinc; acetic acid / 2 h / 20 - 40 °C

4: hydrogen; sodium acetate / 5% Pd(II)/C(eggshell) / ethanol

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 80 °C

6: sodium hydrogencarbonate / dichloromethane; water / 3.67 h / 25 - 26 °C / Cooling with ice

With hydrogen; sodium acetate; sodium hydrogencarbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; zinc; 5% Pd(II)/C(eggshell); In ethanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1262860-01-4
[1-(5-bromo-2-fluoro-phenyl)-2,2-difluoro-eth-(Z)-ylidene]-carbamic acid tert-butyl ester

: 1313526-17-8
[2-tert-butoxycarbonylamino-3,3-difluoro-2-(2-fluorophenyl)-propyl]cyanomethylcarbamic acid 2,2,2-trichloroethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 2 h / 25 °C

2: zinc; acetic acid / 2 h / 20 - 40 °C

3: hydrogen; sodium acetate / 5% Pd(II)/C(eggshell) / ethanol

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 80 °C

5: sodium hydrogencarbonate / dichloromethane; water / 3.67 h / 25 - 26 °C / Cooling with ice

With hydrogen; sodium acetate; sodium hydrogencarbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; zinc; 5% Pd(II)/C(eggshell); In ethanol; dichloromethane; water; acetonitrile;