5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxylic acid

Base Information

• Chemical Name: 5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxylic acid
• CAS No.: 1401529-01-8
• Molecular Formula: C₁₅H₁₅NO₅
• Molecular Weight: 289.288
• Mol file: 1401529-01-8.mol

Synonyms:5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxylic acid

Chemical Property of 5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxylic acid

There total 6 articles about 5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

5-((4-methoxybenzyl)oxy)-4-oxo-4H-pyran-2-carboxylic acid (108352-97-2) + methylamine (74-89-5) → 5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxylic acid (1401529-01-8)

Guidance literature:

at 20 ℃; for 20h; Inert atmosphere;

Reference yield: 67.0%

5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridine-2-carbaldehyde (132182-56-0) → 5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxylic acid (1401529-01-8)

Guidance literature:

5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridine-2-carbaldehyde; With sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; sodium chloride; In tetrahydrofuran; water; tert-butyl alcohol; at 20 ℃; for 1h;

With hydrogenchloride; In water; pH=12;

Reference yield:

p-methoxybenzyl chloride (824-94-2) → 5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxylic acid (1401529-01-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

2.1: ethanol / 20 h / 20 °C

3.1: trimethylamine / dichloromethane; dimethyl sulfoxide / 2 h / 20 °C

4.1: 2-methyl-but-2-ene; sodium dihydrogen phosphate monohydrate; sodium chloride / water; tert-butyl alcohol; tetrahydrofuran / 1 h / 20 °C

4.2: pH 12

With sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; potassium carbonate; sodium chloride; trimethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;

upstream raw materials:

p-methoxybenzyl chloride

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

5-p-methoxybenzyloxy-2-hydroxymethyl-4-pyrone

2-(hydroxymethyl)-5-((4-methoxybenzyl)oxy)-1-methylpyridin-4(1H)-one

Downstream raw materials:

1-(((6R,7R)-7-((Z)-2-((((S)-4-(tert-butoxy)-1-((4-methoxybenzyl)oxy)-1,4-dioxobutan-2-yl)oxy)imino)-2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetamido)-2-(((4-methoxybenzyl)oxy)carbonyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-1-(2-(5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxamido)ethyl)pyrrolidin-1-ium

5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydropyridin-2-carboxamide