8-benzyl-3-((benzyloxycarbonylamino)methyl)-6-chloro-2-(4-methoxyphenyl)-chromone

Base Information

Chemical Name:8-benzyl-3-((benzyloxycarbonylamino)methyl)-6-chloro-2-(4-methoxyphenyl)-chromone
CAS No.:927884-91-1
Molecular Formula:C₃₂H₂₆ClNO₅
Molecular Weight:540.015
Hs Code.:

Synonyms:8-benzyl-3-((benzyloxycarbonylamino)methyl)-6-chloro-2-(4-methoxyphenyl)-chromone

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Chemical Property of 8-benzyl-3-((benzyloxycarbonylamino)methyl)-6-chloro-2-(4-methoxyphenyl)-chromone

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Technology Process of 8-benzyl-3-((benzyloxycarbonylamino)methyl)-6-chloro-2-(4-methoxyphenyl)-chromone

There total 7 articles about 8-benzyl-3-((benzyloxycarbonylamino)methyl)-6-chloro-2-(4-methoxyphenyl)-chromone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 927884-89-7
3-((benzyloxycarbonylamino)methyl)-8-bromo-6-chloro-2-(4-methoxyphenyl)-chromone

: 28493-54-1
benzyltributyltin

: 927884-91-1
8-benzyl-3-((benzyloxycarbonylamino)methyl)-6-chloro-2-(4-methoxyphenyl)-chromone

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 160 ℃; for 0.5h; microwave irradiation;
DOI:10.1021/ol062478z

Reference yield:

: 59443-15-1
5-chloro-3-bromo-2-hydroxyacetophenone

: 927884-91-1
8-benzyl-3-((benzyloxycarbonylamino)methyl)-6-chloro-2-(4-methoxyphenyl)-chromone

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / KOH / ethanol / 20 - 50 °C

2: dimethylamine hydrochloride / dioxane / 0.17 h / 165 °C / microwave irradiation

3: 380 mg / Tf₂NH / acetonitrile / 20 °C

4: 72 percent / SeO₂ / dioxane; H₂O / 1 h / 170 °C / microwave irradiation

5: 64 percent / Pd(PPh₃)4 / dimethylformamide / 0.5 h / 160 °C / microwave irradiation

With potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; selenium(IV) oxide; N,N-dimethylammonium chloride; bis(trifluoromethanesulfonyl)amide; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; acetonitrile; 3: aza-Michael reaction / 5: Stille cross-coupling;
DOI:10.1021/ol062478z

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 927884-91-1
8-benzyl-3-((benzyloxycarbonylamino)methyl)-6-chloro-2-(4-methoxyphenyl)-chromone

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / KOH / ethanol / 20 - 50 °C

2: dimethylamine hydrochloride / dioxane / 0.17 h / 165 °C / microwave irradiation

3: 380 mg / Tf₂NH / acetonitrile / 20 °C

4: 72 percent / SeO₂ / dioxane; H₂O / 1 h / 170 °C / microwave irradiation

5: 64 percent / Pd(PPh₃)4 / dimethylformamide / 0.5 h / 160 °C / microwave irradiation

With potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; selenium(IV) oxide; N,N-dimethylammonium chloride; bis(trifluoromethanesulfonyl)amide; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; acetonitrile; 3: aza-Michael reaction / 5: Stille cross-coupling;
DOI:10.1021/ol062478z