(Z)-2-(1-(4-fluorophenyl)-2-oxo-2-phenylethylidene)cyclobutanone

Base Information

• Chemical Name: (Z)-2-(1-(4-fluorophenyl)-2-oxo-2-phenylethylidene)cyclobutanone
• CAS No.: 1376626-80-0
• Molecular Formula: C₁₈H₁₃FO₂
• Molecular Weight: 280.298
• Mol file: 1376626-80-0.mol

Synonyms:(Z)-2-(1-(4-fluorophenyl)-2-oxo-2-phenylethylidene)cyclobutanone

Chemical Property of (Z)-2-(1-(4-fluorophenyl)-2-oxo-2-phenylethylidene)cyclobutanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-2-(1-(4-fluorophenyl)-2-oxo-2-phenylethylidene)cyclobutanone

There total 2 articles about (Z)-2-(1-(4-fluorophenyl)-2-oxo-2-phenylethylidene)cyclobutanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-cyclopropylidene-2-(4-fluorophenyl)-1-phenylprop-2-en-1-one (1376626-65-1) → (Z)-2-(1-(4-fluorophenyl)-2-oxo-2-phenylethylidene)cyclobutanone (1376626-80-0)

Guidance literature:

With Dess-Martin periodane; palladium dichloride; In dichloromethane; at 20 ℃; for 10h;

DOI:10.1021/ol300927n

Reference yield:

1-(cyclopropylethynyl)-4-fluorobenzene (1263053-65-1) + benzaldehyde (100-52-7) → (Z)-2-(1-(4-fluorophenyl)-2-oxo-2-phenylethylidene)cyclobutanone (1376626-80-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 5 h / -78 °C

1.2: -78 - 40 °C

1.3: 0.17 h / 20 °C

2.1: Dess-Martin periodane; palladium dichloride / dichloromethane / 10 h / 20 °C

With n-butyllithium; Dess-Martin periodane; palladium dichloride; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/ol300927n

upstream raw materials:

3-cyclopropylidene-2-(4-fluorophenyl)-1-phenylprop-2-en-1-one

1-(cyclopropylethynyl)-4-fluorobenzene

benzaldehyde