3-cyclopropylidene-2-(4-fluorophenyl)-1-phenylprop-2-en-1-one

Base Information

• Chemical Name: 3-cyclopropylidene-2-(4-fluorophenyl)-1-phenylprop-2-en-1-one
• CAS No.: 1376626-65-1
• Molecular Formula: C₁₈H₁₃FO
• Molecular Weight: 264.299
• Mol file: 1376626-65-1.mol

Synonyms:3-cyclopropylidene-2-(4-fluorophenyl)-1-phenylprop-2-en-1-one

Chemical Property of 3-cyclopropylidene-2-(4-fluorophenyl)-1-phenylprop-2-en-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-cyclopropylidene-2-(4-fluorophenyl)-1-phenylprop-2-en-1-one

There total 1 articles about 3-cyclopropylidene-2-(4-fluorophenyl)-1-phenylprop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.0%

1-(cyclopropylethynyl)-4-fluorobenzene (1263053-65-1) + benzaldehyde (100-52-7) → 3-cyclopropylidene-2-(4-fluorophenyl)-1-phenylprop-2-en-1-one (1376626-65-1)

Guidance literature:

1-(cyclopropylethynyl)-4-fluorobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 5h;

benzaldehyde; In tetrahydrofuran; hexane; at -78 - 40 ℃;

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 0.166667h;

DOI:10.1021/ol300927n

Reference yield: 94.0%

3-cyclopropylidene-2-(4-fluorophenyl)-1-phenylprop-2-en-1-one (1376626-65-1) + triphenylphosphine (603-35-0) → (Z)-3-(diphenylphosphoryl)-2-(4-fluorophenyl)-3-(1-hydroxycyclopropyl)-1-phenylprop-2-en-1-one (1441002-32-9)

Guidance literature:

With water; oxygen; In acetone; at 0 ℃; for 10h; stereoselective reaction;

DOI:10.1021/jo400610q

Reference yield: 85.0%

3-cyclopropylidene-2-(4-fluorophenyl)-1-phenylprop-2-en-1-one (1376626-65-1) → 3,5-bis(4-fluorophenyl)-3a,7a-ethylene-2,4-diphenyl-3aH-spiro[benzofuran-6,1'-cyclopropan]-7(7aH)-one (1425853-98-0)

Guidance literature:

With copper(l) chloride; In tetrahydrofuran; at 50 ℃; Inert atmosphere;

DOI:10.1021/jo302312y

upstream raw materials:

1-(cyclopropylethynyl)-4-fluorobenzene

benzaldehyde

Downstream raw materials:

(Z)-2-(1-(4-fluorophenyl)-2-oxo-2-phenylethylidene)cyclobutanone

3,5-bis(4-fluorophenyl)-3a,7a-ethylene-2,4-diphenyl-3aH-spiro[benzofuran-6,1'-cyclopropan]-7(7aH)-one

(Z)-3-(diphenylphosphoryl)-2-(4-fluorophenyl)-3-(1-hydroxycyclopropyl)-1-phenylprop-2-en-1-one