5-[4-(methylsulfonyl)phenoxy]-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxamide

Base Information

Chemical Name:5-[4-(methylsulfonyl)phenoxy]-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxamide
CAS No.:1233540-69-6
Molecular Formula:C₂₁H₂₂N₂O₆S
Molecular Weight:430.481
Hs Code.:

Synonyms:5-[4-(methylsulfonyl)phenoxy]-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxamide

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Chemical Property of 5-[4-(methylsulfonyl)phenoxy]-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxamide

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Technology Process of 5-[4-(methylsulfonyl)phenoxy]-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxamide

There total 11 articles about 5-[4-(methylsulfonyl)phenoxy]-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1233540-68-5
5-[4-(methylsulfonyl)phenoxy]-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxylic acid

: 1233540-69-6
5-[4-(methylsulfonyl)phenoxy]-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxamide

Guidance literature:: With N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 10 - 35 ℃; for 12h;

Reference yield:

: 129464-01-3
2-(benzyloxy)-4-fluoro-1-nitrobenzene

: 1233540-69-6
5-[4-(methylsulfonyl)phenoxy]-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2.1: Oxone / water; tetrahydrofuran; methanol / 4 h / 10 - 35 °C

3.1: water; calcium chloride; iron / ethanol / 2 h / 80 °C

4.1: hydrogenchloride; sodium nitrite / acetonitrile; ethanol; water / -5 - 10 °C

4.2: 2.67 h / -13 - -11 °C

5.1: toluene-4-sulfonic acid / toluene / 0.17 h / 80 °C

6.1: hydrogen / palladium 10% on activated carbon / ethanol; water; tetrahydrofuran / 4 h / 10 - 35 °C

7.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / tetrahydrofuran / 20 h / 70 °C

8.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 0.67 h / 60 °C

9.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-hydroxybenzotriazole ammonium salt / N,N-dimethyl-formamide / 12 h / 10 - 35 °C

With hydrogenchloride; Oxone; N-hydroxybenzotriazole ammonium salt; tributylphosphine; water; hydrogen; iron; potassium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; calcium chloride; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 446-36-6
5-fluoro-2-nitrophenol

: 1233540-69-6
5-[4-(methylsulfonyl)phenoxy]-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 10 - 35 °C / Cooling with ice

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

3.1: Oxone / water; tetrahydrofuran; methanol / 4 h / 10 - 35 °C

4.1: water; calcium chloride; iron / ethanol / 2 h / 80 °C

5.1: hydrogenchloride; sodium nitrite / acetonitrile; ethanol; water / -5 - 10 °C

5.2: 2.67 h / -13 - -11 °C

6.1: toluene-4-sulfonic acid / toluene / 0.17 h / 80 °C

7.1: hydrogen / palladium 10% on activated carbon / ethanol; water; tetrahydrofuran / 4 h / 10 - 35 °C

8.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / tetrahydrofuran / 20 h / 70 °C

9.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 0.67 h / 60 °C

10.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-hydroxybenzotriazole ammonium salt / N,N-dimethyl-formamide / 12 h / 10 - 35 °C

With hydrogenchloride; Oxone; N-hydroxybenzotriazole ammonium salt; tributylphosphine; water; hydrogen; iron; potassium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; calcium chloride; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;