129464-01-3

Basic information

• Product Name: 2-(Benzyloxy)-4-fluoro-1-nitrobenzene
• Synonyms: 2-(Benzyloxy)-4-fluoro-1-nitrobenzene
• CAS NO: 129464-01-3
• Molecular Formula: C₁₃H₁₀FNO₃
• Molecular Weight: 247.2218032
• Mol File: 129464-01-3.mol

Chemical Properties

• Boiling Point: 370.5±27.0 °C(Predicted)
• Appearance: /
• Density: 1.299±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(Benzyloxy)-4-fluoro-1-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Benzyloxy)-4-fluoro-1-nitrobenzene(129464-01-3)
• EPA Substance Registry System: 2-(Benzyloxy)-4-fluoro-1-nitrobenzene(129464-01-3)

Safety Data

• Hazardous Substances Data: 129464-01-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-(Benzyloxy)-4-fluoro-1-nitrobenzene is used as a building block in organic synthesis for the creation of various synthetic organic compounds. Its unique structure allows it to be a versatile component in the formation of complex molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-(Benzyloxy)-4-fluoro-1-nitrobenzene is utilized as a pharmaceutical intermediate. It plays a crucial role in the development of new drugs, contributing to the advancement of medicinal chemistry by providing a foundation for the synthesis of potential therapeutic agents.

Upstream product

• 446-36-6 5-fluoro-2-nitrophenol 
• 100-39-0 benzyl bromide 
• 584-08-7 potassium carbonate 
• 100-51-6 benzyl alcohol 
• 446-35-5 2,4-Difluoronitrobenzene 
• 22379-62-0 potassium benzyloxide 
• 620-05-3 iodomethylbenzene 

Downstream Products

• 215321-70-3 N-Methyl-N-(2-hydroxyethyl)-3-benzyloxy-4-nitroaniline 
• 941594-41-8 2-(benzyloxy)-1-nitro-4-phenoxybenzene 
• 941594-46-3 2-(3-benzyloxy-4-nitro-phenyl)-malonic acid tert-butyl ester ethyl ester 
• 941594-52-1 2-benzyloxy-1-nitro-4-phenylsulfanylbenzene 
• 441713-49-1 diethyl 2-(3-(benzyloxy)-4-nitrophenyl)malonate 
• 941594-53-2 3-benzyloxy-4-nitrobenzenethiol 
• 221615-94-7 3-(benzyloxy)-4-nitrophenol 
• 256453-83-5 dimethyl-(3-benzyloxy-4-nitrophenyl)malonate 
• 861958-73-8 4-(bis(3-benzyloxy-4-nitrophenyl)amino)methyl benzoate 
• 640289-16-3 4,4'-di-(4-benzyloxy-3-nitrophenyloxy)-tetraphenylmethane 
• 925463-50-9 trifluoro-methanesulfonic acid 3-benzyloxy-5,8-bis-(tert-butyl-diphenyl-silanyloxymethyl)-4-(toluene-4-sulfonylamino)-5,8-dihydro-naphthalen-1-yl ester 
• 925463-48-5 N-[2-benzyloxy-5,8-bis-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-5,8-dihydro-naphthalen-1-yl]-4-methyl-benzenesulfonamide 
• 925463-70-3 1-methyl-1H-indole-2-carboxylic acid {3-[7-benzyloxy-3-methyl-1-(toluene-4-sulfonyl)-5-triisopropylsilanyloxy-1H-indol-4-yl]-2-methoxymethoxy-propyl}-amide 
• 925463-71-4 trifluoro-methanesulfonic acid 7-benzyloxy-4-{2-methoxymethoxy-3-[(1-methyl-1H-indole-2-carbonyl)-amino]-propyl}-3-methyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester 

Relevant articles and documents

LIPOXYGENASE INHIBITORS

Various embodiments of the present disclosure are directed to compounds having Formula (I), Formula (IA), Formula (IB), Formula (IC), Formula (ID), Formula (IE), and/or pharmaceutically acceptable salts thereof. The compounds can be suitable for inhibiting lipoxygenases, and/or treating associated diseases, such as Alzheimer's disease. In some embodiments, the compounds may be administered to a patient as part of a pharmaceutical formulation.

CELL SURFACE RECEPTOR BINDING COMPOUNDS AND CONJUGATES

The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface receptor, such as a mannose-6-phosphate receptor (M6PR) or a cell surface asialoglycoprotein receptor (ASGPR). The cell surface M6PR or ASGPR binding compounds can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor, e.g., M6PR or ASGPR. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided are methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.

INHIBITORS OF VAP-1

Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

HMOX1 inducers

The present invention is related to compounds of structure (I) as heme oxygenase 1 (HMOX 1) inducers. The present invention is also related a method of controlling the activity or the amount, or both the activity and the amount, of heme-oxygenase 1 in a mammalian subject. The definitions of the variables are provided herein.

AGRICULTURAL CHEMICALS

The present invention relates to picolinic acid derivatives that are useful in treating fungal diseases ofplants.

Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and β-selectivity of liver X receptor agonist

Our research found that the 2-hydroxyacetophenone derivative is an outstanding linker between the 1,1-bistrifluoromethylcarbinol moiety and the imidazolidine-2,4-dione moiety to enhance the potency and β-selectivity of liver X receptor (LXR) agonist in ou

N2,N4-BIS(4-(PIPERAZINE-1-YL)PHENYL)PIRIMIDINE-2,4-DIAMINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER

The present invention relates to a N2,N4-bis(4-(piperazine-1-yl)phenyl)pirimidine-2,4-diamine derivative or a pharmaceutically acceptable salt thereof, and to a composition containing same as an active ingredient for preventing or treating cancer. Since the compound according to the present invention has good effects in inhibiting the activities of anaplastic lymphoma kinase (ALK) and activated Cdc42-associated kinase (ACK1), the compound can have improved therapeutic effects against cancer cells having ALK fusion proteins such as EML4-ALK and NPM-ALK and is expected to be effective in preventing the recurrence of cancer. Therefore, the compound can be effectively used as a composition for preventing or treating cancer.

N2,N4-BIS(4-(PIPERAZINE-1-YL)PHENYL)PIRIMIDINE-2,4-DIAMINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER

Disclosed herein are a new N2,N4-bis(4-(piperazin-1-yl)phenyl)pyrimidin-2,4-diamine derivative or a pharmaceutically acceptable salt thereof and a pharmaceutical composition for the prevention or treatment of cancers containing the same as an active ingredient. The compound of the present invention has excellent inhibitory effects against the activities of anaplastic lymphoma kinase (ALK) and activated cdc42-associated kinase (ACK1) and thus can improve the therapeutic effects on the treatment of cancer cells having anaplastic lymphoma kinase fusion proteins such as EML4-ALK and NPM-ALK, and also effectively prevent the recurrence of cancers thus being useful as a pharmaceutical composition for the prevention and treatment of cancers.

Nonpolar solvent a key for highly regioselective SNAr reaction in the case of 2,4-difluoronitrobenzene

A practical and highly regioselective aromatic nucleophilic substitution reaction for the substrate 2,4-difluoronitrobenzene is demonstrated with various O/S/N-nucleophiles. Solvent screens substantiate the role of a nonpolar solvent in ortho-selective nucleophilic substitution through a six-membered polar transition state.

NITROGEN-CONTAINING CONDENSED HETEROCYCLIC COMPOUND

There are provided compounds represented by the following general formula (I) or pharmaceutically acceptable salts of thereof, which have a superior monoacylglycerol acyltransferase 2 inhibitory action: wherein Ring A represents a partially saturated heteroaryl group, an aryl group or a heteroaryl group, RB represents a C4-18 alkyl group, a C3-8 cycloalkyl group, a partially saturated aryl group, an aryl group, or the following formula (II): wherein V represents the formula -CR11R12-, -CO-, -CO-O-, or -CO-NH-, W represents a single bond or a C1-3 alkylene group, and Ring B represents a C3-8 cycloalkyl group, a C3-8 cycloalkenyl group, a partially saturated heteroaryl group, a saturated heterocyclyl group, an aryl group, or a heteroaryl group, Y represents a nitrogen atom or the formula N+(RF), RF represents a C1-4 alkyl group, and m and n, which may be the same or different, each represent an integer of 0 or 1.