methyl (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-3-methyl-2-propenoate

Base Information

Chemical Name:methyl (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-3-methyl-2-propenoate
CAS No.:1028289-77-1
Molecular Formula:C₁₉H₂₃ClN₂O₂
Molecular Weight:346.857
Hs Code.:

Synonyms:methyl (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-3-methyl-2-propenoate

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Chemical Property of methyl (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-3-methyl-2-propenoate

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Technology Process of methyl (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-3-methyl-2-propenoate

There total 8 articles about methyl (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-3-methyl-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17849-38-6
2-Chlorobenzyl alcohol

: 1028289-77-1
methyl (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-3-methyl-2-propenoate

Guidance literature:: Multi-step reaction with 7 steps

1: diisopropylethylamine / CH₂Cl₂ / 0.33 h / -78 °C

2: CH₂Cl₂ / 18 h / Ambient temperature

3: 10percent aq. NaOH / methanol / 4 h / Heating

4: 93 percent / MnO₂ / CH₂Cl₂ / 19 h / Ambient temperature

5: 92 percent / tetrahydrofuran; diethyl ether / 1.25 h / -78 °C

6: 59 percent / activated MnO₂ / toluene / 90 h / 60 - 90 °C

7: 1.) NaH / 1.) DME, 45 deg C, 30 min, 2.) DME, 50 deg C, 45 min

With manganese(IV) oxide; sodium hydroxide; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1021/jm00099a013

Reference yield:

: 68283-19-2
2-n-butyl-4-(hydroxymethyl)imidazole

: 1028289-77-1
methyl (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-3-methyl-2-propenoate

Guidance literature:: Multi-step reaction with 7 steps

1: 83 percent / 19 h / Ambient temperature

2: CH₂Cl₂ / 18 h / Ambient temperature

3: 10percent aq. NaOH / methanol / 4 h / Heating

4: 93 percent / MnO₂ / CH₂Cl₂ / 19 h / Ambient temperature

5: 92 percent / tetrahydrofuran; diethyl ether / 1.25 h / -78 °C

6: 59 percent / activated MnO₂ / toluene / 90 h / 60 - 90 °C

7: 1.) NaH / 1.) DME, 45 deg C, 30 min, 2.) DME, 50 deg C, 45 min

With manganese(IV) oxide; sodium hydroxide; sodium hydride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1021/jm00099a013

Reference yield:

: 133486-41-6
1-acetyl-4-acetoxymethyl-2-n-butylimidazole

: 1028289-77-1
methyl (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-3-methyl-2-propenoate

Guidance literature:: Multi-step reaction with 6 steps

1: CH₂Cl₂ / 18 h / Ambient temperature

2: 10percent aq. NaOH / methanol / 4 h / Heating

3: 93 percent / MnO₂ / CH₂Cl₂ / 19 h / Ambient temperature

4: 92 percent / tetrahydrofuran; diethyl ether / 1.25 h / -78 °C

5: 59 percent / activated MnO₂ / toluene / 90 h / 60 - 90 °C

6: 1.) NaH / 1.) DME, 45 deg C, 30 min, 2.) DME, 50 deg C, 45 min

With manganese(IV) oxide; sodium hydroxide; sodium hydride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1021/jm00099a013