3-[3-(3,5-Dihydroxy-4-methoxy-6-methyloxan-2-yl)oxy-4,5-dihydroxy-6-methyloxan-2-yl]oxy-8-hydroxy-15-methyl-11,18-dioxapentacyclo[10.6.2.02,7.09,19.016,20]icosa-1(19),2(7),3,5,8,12(20),13,15-octaene-10,17-dione

Base Information

Chemical Name:3-[3-(3,5-Dihydroxy-4-methoxy-6-methyloxan-2-yl)oxy-4,5-dihydroxy-6-methyloxan-2-yl]oxy-8-hydroxy-15-methyl-11,18-dioxapentacyclo[10.6.2.02,7.09,19.016,20]icosa-1(19),2(7),3,5,8,12(20),13,15-octaene-10,17-dione
CAS No.:6377-18-0
Molecular Formula:C₃₂H₃₂O₁₄
Molecular Weight:640.598
Hs Code.:29419000
NSC Number:5159
DSSTox Substance ID:DTXSID50871929
Wikidata:Q105212535
ChEMBL ID:CHEMBL357992
Mol file:6377-18-0.mol

3-[3-(3,5-Dihydroxy-4-methoxy-6-methyloxan-2-yl)oxy-4,5-dihydroxy-6-methyloxan-2-yl]oxy-8-hydroxy-15-methyl-11,18-dioxapentacyclo[10.6.2.02,7.09,19.016,20]icosa-1(19),2(7),3,5,8,12(20),13,15-octaene-10,17-dione

Synonyms:NSC5159;MLS002701890;SMR001565476;NSC-5159;Neuro_000004;MLS003559964;SCHEMBL973724;CHEMBL357992;DTXSID50871929;PONPPNYZKHNPKZ-UHFFFAOYSA-N;3-[(2S,3R,4S,5R,6R)-3-[(2R,3R,4S,5S,6R)-3,5-dihydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4,5-dihydroxy-6-methyloxan-2-yl]oxy-8-hydroxy-15-methyl-11,18-dioxapentacyclo[10.6.2.02,7.09,19.016,20]icosa-1(19),2(7),3,5,8,12(20),13,15-octaene-10,17-dione;AKOS004902212;6-Hydroxy-1-methyl-5,12-dioxo-5,12-dihydrobenzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-10-yl 6-deoxy-2-O-(6-deoxy-3-O-methylhexopyranosyl)hexopyranoside;6-Hydroxy-1-methyl-5,12-dioxo-5,12-dihydrobenzo[h]chromeno[5,4,3-cde]chromen-10-yl 6-deoxy-2-O-(6-deoxy-3-O-methylhexopyranosyl)hexopyranoside;6-Hydroxy-1-methyl-5,12-dioxo-5,12-dihydrobenzo[h]chromeno[5,4,3-cde]chromen-10-yl 6-deoxy-2-O-(6-deoxy-3-O-methylhexopyranosyl)hexopyranoside #;Benzo[h][1]benzopyrano[5,3-cde][1]benzopyran-5,12-dione, 10-[[6-deoxy-2-O-(6-deoxy-3-O-methyl-.alpha.-D-galactopyranosyl)-.beta.-D-galactopyranosyl]oxy]-6-hydroxy-1-methyl-;WLN: T B66 K666 2AB T HVO SVOJ F1 QQ LO- BT6OTJ DQ EQ F1 CO- BT6OTJ CQ DO1 EQ F1;WLN: T B66 K666 2AB T HVO SVOJ F1 QQ LO- BT6OTJ DQ EQ F1 CO- BT6OTJ CQ DO1 EQ F1 &QH 2

Suppliers and Price of 3-[3-(3,5-Dihydroxy-4-methoxy-6-methyloxan-2-yl)oxy-4,5-dihydroxy-6-methyloxan-2-yl]oxy-8-hydroxy-15-methyl-11,18-dioxapentacyclo[10.6.2.02,7.09,19.016,20]icosa-1(19),2(7),3,5,8,12(20),13,15-octaene-10,17-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Chartreusin
5mg
$ 426.00

Usbiological
Chartreusin
5mg
$ 385.00

TRC
Chartreusin
2.5mg
$ 205.00

TRC
Chartreusin
1mg
$ 130.00

Cayman Chemical
Chartreusin ≥98%
1mg
$ 43.00

Cayman Chemical
Chartreusin ≥98%
5mg
$ 127.00

American Custom Chemicals Corporation
CHARTREUSIN 95.00%
25MG
$ 1058.40

American Custom Chemicals Corporation
CHARTREUSIN 95.00%
5MG
$ 496.07

AK Scientific
Chartreusin
5mg
$ 257.00

AK Scientific
Chartreusin
1mg
$ 152.00

Total 11 raw suppliers

Chemical Property of 3-[3-(3,5-Dihydroxy-4-methoxy-6-methyloxan-2-yl)oxy-4,5-dihydroxy-6-methyloxan-2-yl]oxy-8-hydroxy-15-methyl-11,18-dioxapentacyclo[10.6.2.02,7.09,19.016,20]icosa-1(19),2(7),3,5,8,12(20),13,15-octaene-10,17-dione

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:185℃
Refractive Index:1.6130 (estimate)
Boiling Point:945.5°C at 760 mmHg
Flash Point:307.8°C
PSA：207.72000
Density:1.63g/cm³
LogP:1.36980
Storage Temp.:2-8°C
Solubility.:Chloroform (Slightly, Heated), Methanol (Slightly), Pyridine (Slightly)
Water Solubility.:15mg/L(25 oC)
XLogP3:2.1
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:5
Exact Mass:640.17920569
Heavy Atom Count:46
Complexity:1150

Purity/Quality:: Chartreusin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 40
Safety Statements: 22-36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C(C(C(C(O1)OC2=CC=CC3=C2C4=C5C6=C(C=CC(=C6C(=O)O4)C)OC(=O)C5=C3O)OC7C(C(C(C(O7)C)O)OC)O)O)O
Uses Chartreusin is an antitumour antibiotic that binds to GC-rich tracts in DNA, with a clear preference for B-DNA over Z-DNA. It inhibits RNA synthesis and causes single-strand scission of DNA via the formation of free radicals. Chartreusin is also a potent inhibitor of topoisomerase II. Chartreusin is an antitumor antibiotic that binds to GC-rich tracts in DNA, with a clear preference for B-DNA over Z-DNA. It inhibits RNA synthesis and causes single-strand scission of DNA via the formation of free radicals. Chartreusin is also a potent inhibitor of topoisomerase II. Chartreusin is an antiproliferative agent that inhibits topoisomerase II.

Technology Process of 3-[3-(3,5-Dihydroxy-4-methoxy-6-methyloxan-2-yl)oxy-4,5-dihydroxy-6-methyloxan-2-yl]oxy-8-hydroxy-15-methyl-11,18-dioxapentacyclo[10.6.2.02,7.09,19.016,20]icosa-1(19),2(7),3,5,8,12(20),13,15-octaene-10,17-dione

There total 1 articles about 3-[3-(3,5-Dihydroxy-4-methoxy-6-methyloxan-2-yl)oxy-4,5-dihydroxy-6-methyloxan-2-yl]oxy-8-hydroxy-15-methyl-11,18-dioxapentacyclo[10.6.2.02,7.09,19.016,20]icosa-1(19),2(7),3,5,8,12(20),13,15-octaene-10,17-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: C₃₃H₃₂O₁₄

: C₃₃H₃₄O₁₆

: C₃₂H₃₂O₁₄

: C₃₄H₃₆O₁₆

: 6377-18-0
Lambdamycin

Guidance literature:: C₃₃H₃₂O₁₄; With flavin reductase from Escherichia coli; dioxygenase ChaP; flavin adenine dinucleotide; NADH; In aq. buffer; at 30 ℃; for 0.5h; Enzymatic reaction;

methanol; In aq. buffer;
DOI:10.1021/jacs.8b06623