Technology Process of 3-Hydroxy-5-iodo-4-methoxybenzaldehyde
There total 5 articles about 3-Hydroxy-5-iodo-4-methoxybenzaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-iodo-4,5-dihydroxybenzaldehyde;
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.833333h;
Inert atmosphere;
methyl iodide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 5h;
regioselective reaction;
Inert atmosphere;
DOI:10.1080/00304948.2012.643700
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Sn, 48percent HBr / 0.67 h / 65 °C
With
tin; hydrogen bromide;
DOI:10.1021/jm00345a012
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: pyridine; aluminum (III) chloride / dichloromethane / 16.33 h / 50 °C / Inert atmosphere; Reflux
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.83 h / 20 °C / Inert atmosphere
2.2: 5 h / 20 °C / Inert atmosphere
With
pyridine; aluminum (III) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/00304948.2012.643700
