3-Hydroxy-5-iodo-4-methoxybenzaldehyde

Base Information

Chemical Name:3-Hydroxy-5-iodo-4-methoxybenzaldehyde
CAS No.:54246-07-0
Molecular Formula:C₈H₇IO₃
Molecular Weight:278.046
Hs Code.:
ChEMBL ID:CHEMBL89321
DSSTox Substance ID:DTXSID701284149

Synonyms:3-hydroxy-5-iodo-4-methoxybenzaldehyde;54246-07-0;CHEMBL89321;DTXSID701284149;3-Hydroxy-5-iodo-4-methoxy-benzaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Hydroxy-5-iodo-4-methoxybenzaldehyde

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:277.94399
Heavy Atom Count:12
Complexity:162

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1I)C=O)O

Technology Process of 3-Hydroxy-5-iodo-4-methoxybenzaldehyde

There total 5 articles about 3-Hydroxy-5-iodo-4-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 54246-05-8
3-iodo-4,5-dihydroxybenzaldehyde

: 74-88-4
methyl iodide

: 54246-07-0
3-hydroxy-5-iodo-4-methoxybenzaldehyde

Guidance literature:: 3-iodo-4,5-dihydroxybenzaldehyde; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 0.833333h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 5h; regioselective reaction; Inert atmosphere;
DOI:10.1080/00304948.2012.643700

Reference yield:

: 80547-72-4
acetic acid 5-formyl-2-methoxy-3-nitrophenyl ester

: 54246-07-0
3-hydroxy-5-iodo-4-methoxybenzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: Sn, 48percent HBr / 0.67 h / 65 °C

With tin; hydrogen bromide;
DOI:10.1021/jm00345a012

Reference yield:

: 5438-36-8
5-iodovaniline

: 54246-07-0
3-hydroxy-5-iodo-4-methoxybenzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; aluminum (III) chloride / dichloromethane / 16.33 h / 50 °C / Inert atmosphere; Reflux

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.83 h / 20 °C / Inert atmosphere

2.2: 5 h / 20 °C / Inert atmosphere

With pyridine; aluminum (III) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/00304948.2012.643700