Technology Process of 1-cyclohexyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole
There total 3 articles about 1-cyclohexyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate;
In
1,4-dioxane;
at 100 ℃;
for 4h;
Inert atmosphere;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C
2: sodium dithionite; ammonium hydroxide / water; tetrahydrofuran / 1 h / 20 °C
3: acetic acid / 0.17 h / 20 °C
4: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 12 h / Reflux
With
bis-triphenylphosphine-palladium(II) chloride; ammonium hydroxide; sodium dithionite; potassium acetate; potassium carbonate; acetic acid;
In
tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2019.07.042
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sulfuric acid; nitric acid / dichloromethane / 0.5 h / 0 - 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C
3: sodium dithionite; ammonium hydroxide / water; tetrahydrofuran / 1 h / 20 °C
4: acetic acid / 0.17 h / 20 °C
5: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 12 h / Reflux
With
bis-triphenylphosphine-palladium(II) chloride; ammonium hydroxide; sodium dithionite; sulfuric acid; nitric acid; potassium acetate; potassium carbonate; acetic acid;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2019.07.042
