(R)-(Z)-7-<(benzyloxy)methoxy>-4-methyl-5-(trimethylsilyl)-5-hepten-3-one

Base Information

Chemical Name:(R)-(Z)-7-<(benzyloxy)methoxy>-4-methyl-5-(trimethylsilyl)-5-hepten-3-one
CAS No.:103563-51-5
Molecular Formula:C₁₉H₃₀O₃Si
Molecular Weight:334.531
Hs Code.:

Synonyms:(R)-(Z)-7-<(benzyloxy)methoxy>-4-methyl-5-(trimethylsilyl)-5-hepten-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-(Z)-7-<(benzyloxy)methoxy>-4-methyl-5-(trimethylsilyl)-5-hepten-3-one

Chemical Property:

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Technology Process of (R)-(Z)-7-<(benzyloxy)methoxy>-4-methyl-5-(trimethylsilyl)-5-hepten-3-one

There total 6 articles about (R)-(Z)-7-<(benzyloxy)methoxy>-4-methyl-5-(trimethylsilyl)-5-hepten-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Methanesulfonic acid (Z)-(S)-5-benzyloxymethoxy-2-ethyl-2-hydroxy-1-methyl-3-trimethylsilanyl-pent-3-enyl ester

: 103563-51-5
(R)-(Z)-7-<(benzyloxy)methoxy>-4-methyl-5-(trimethylsilyl)-5-hepten-3-one

Guidance literature:: With triethylaluminum; In hexane; dichloromethane; at -78 ℃; for 1h; Yield given;
DOI:10.1021/ja00277a028

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 103563-51-5
(R)-(Z)-7-<(benzyloxy)methoxy>-4-methyl-5-(trimethylsilyl)-5-hepten-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: NaH

2: EtMgBr

3: DIBAL, Br₂

4: n-BuLi / tetrahydrofuran; diethyl ether; hexane / 0.5 h / -100 °C

5: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

6: Et₃Al / CH₂Cl₂; hexane / 1 h / -78 °C

With n-butyllithium; ethylmagnesium bromide; bromine; triethylaluminum; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/ja00277a028

Reference yield:

: 103590-65-4
((E)-3-Benzyloxymethoxy-1-bromo-propenyl)-trimethyl-silane

: 103563-51-5
(R)-(Z)-7-<(benzyloxy)methoxy>-4-methyl-5-(trimethylsilyl)-5-hepten-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: n-BuLi / tetrahydrofuran; diethyl ether; hexane / 0.5 h / -100 °C

2: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

3: Et₃Al / CH₂Cl₂; hexane / 1 h / -78 °C

With n-butyllithium; triethylaluminum; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/ja00277a028