3-chloro-2-methoxy-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone

Base Information

Chemical Name:3-chloro-2-methoxy-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone
CAS No.:870962-57-5
Molecular Formula:C₁₉H₁₈ClN₃O₆
Molecular Weight:419.821
Hs Code.:

Synonyms:3-chloro-2-methoxy-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone

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Chemical Property of 3-chloro-2-methoxy-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone

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Technology Process of 3-chloro-2-methoxy-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone

There total 8 articles about 3-chloro-2-methoxy-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.8%

: 870959-59-4
2,3-dichloro-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone

: 67-56-1
methanol

: 870962-57-5
3-chloro-2-methoxy-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone

Guidance literature:: With sodium phenoxide; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1021/jm050559f

Reference yield:

: 870962-58-6
4-[(3-chloro-4-methoxy-2,5-dimethoxyphenyl)amino]-6-methoxy-7-(2-methoxyethoxy)quinoline-3-carbonitrile

: 870962-57-5
3-chloro-2-methoxy-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone

Guidance literature:: 4-[(3-chloro-4-methoxy-2,5-dimethoxyphenyl)amino]-6-methoxy-7-(2-methoxyethoxy)quinoline-3-carbonitrile; With ammonium cerium(IV) nitrate; In water; acetonitrile; at 30 ℃; for 0.833333h; Heating / reflux;

With hydrogenchloride; In water; for 0.25h;

Reference yield:

: 247569-96-6
3-methoxy-4-(2-methoxyethoxy)benzonitrile

: 870962-57-5
3-chloro-2-methoxy-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone

Guidance literature:: Multi-step reaction with 6 steps

1: NH₄NO₃; trifluoroacetic anhydride / CHCl₃ / 2 h / Heating

2: cyclohexene / Pd/C / ethanol / Heating

3: 7 h / Heating

4: 37 percent / AcONa / 1 h / 110 °C

5: 52 percent / aq. Ce(NH₄)2(NO₃)6 / CHCl₃; acetonitrile / 1 h / Heating

6: 35.8 percent / NaOPh*3H₂O / CH₂Cl₂ / 1.5 h / 20 °C

With ammonium nitrate; ammonium cerium(IV) nitrate; sodium acetate; sodium phenoxide; trifluoroacetic anhydride; cyclohexene; palladium on activated charcoal; In ethanol; dichloromethane; chloroform; acetonitrile;
DOI:10.1021/jm050559f