(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)methanone

Base Information

Chemical Name:(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)methanone
CAS No.:1361392-16-6
Molecular Formula:C₂₅H₃₄N₄O₄S
Molecular Weight:486.635
Hs Code.:

Synonyms:(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)methanone

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Chemical Property of (4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)methanone

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Technology Process of (4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)methanone

There total 3 articles about (4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3685-22-1,3685-26-5,17419-81-7
4-hydroxycyclohexanecarboxylic acid

: 1361392-16-6
(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / 2,4-dichlorophenoxyacetic acid dimethylamine; mineral oil / 0.5 h / 0 - 20 °C

1.2: 15 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 20 °C

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 2,4-dichlorophenoxyacetic acid dimethylamine; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 40517-43-9
1-(chloromethyl)-4-(methylsulfonyl)benzene

: 1361392-16-6
(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 22821-77-8
p-methylsulfonylbenzyl alcohol

: 1361392-16-6
(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)(4-(4-(methylsulfonyl)benzyl)piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 15 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;