40517-43-9

Usage

Uses

Used in Pharmaceutical Industry:
P-(METHYLSULFONYL)BENZYL CHLORIDE is used as a synthetic intermediate for the production of various pharmaceuticals. Its unique chemical structure allows for the creation of a wide range of medicinal compounds, contributing to the development of new treatments and therapies.
Used in Agrochemical Industry:
In the agrochemical sector, P-(METHYLSULFONYL)BENZYL CHLORIDE is utilized as a key component in the synthesis of different agrochemicals. Its reactivity and functional groups make it suitable for the development of effective pesticides and other agricultural products.
Used in Organic Chemistry Research:
P-(METHYLSULFONYL)BENZYL CHLORIDE is employed as a reagent in organic chemistry reactions, particularly for the formation of carbon-carbon and carbon-nitrogen bonds. Its ability to participate in various chemical transformations makes it a valuable tool for researchers in the field of organic synthesis and compound development.

InChI:InChI=1/C8H9ClO2S/c1-12(10,11)8-4-2-7(6-9)3-5-8/h2-5H,6H2,1H3

Upstream product

• 22821-77-8 p-methylsulfonylbenzyl alcohol 
• 3185-99-7 Methyl p-tolyl sulfone 
• 6274-54-0 methylsulfonyl-4 benzoate d'ethyle 
• 3446-90-0 4-(methylthio)benzyl alcohol 
• 58472-47-2 4-methylsulfinylbenzyl chloride 
• 124-63-0 methanesulfonyl chloride 
• 4052-30-6 4-methylsulfonylbenzoic acid 
• 13205-48-6 4-(methylthio)benzoic acid 
• 22821-70-1 methyl 4-(methanesulfonyl)benzoate 
• 100960-84-7 (4-iodomethyl-phenyl)-methyl sulfone 

Downstream Products

• 130935-96-5 (E)-1,2-bis(4-(methylsulfonyl)phenyl)ethene 
• 616881-75-5 sodium (4-(methylsulfonyl)phenyl)methanesulfonate 
• 100960-84-7 (4-iodomethyl-phenyl)-methyl sulfone 
• 121083-05-4 (-)6,8-difluoro-9-p-methylsulfonyl benzyl-1,2,3,4-tetrahydrocarbazol-1-yl-acetic acid 
• 301220-85-9 4-((1-(4-methylsulfonylbenzyl)-3-ethyl)pyrazol-4-yl)-N-t-butoxylcarbonylpiperidine 

Relevant academic research and scientific papers

SPIRO COMPOUNDS AS GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein A, R, L, Z, Q1, Q2 and n have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.

PYRROLIDINE GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein A, W, R3b, Z and p have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.

Derivatives of 1H-imidazole-4,5-dicarboxamide and Use Thereof in Preparation of Anticoccidial Drugs

Disclosed are derivatives of 1H-imidazole-4,5-dicarboxamide and use thereof in preparation of anticoccidial drugs. The derivatives have structural formulae as shown in formulae (I) to (VI). The derivatives of 1H-imidazole-4,5-dicarboxamide as disclosed in the present invention have significant anticoccidial effect, especially against coccidia that show a resistance to other anticoccidial drugs, and thus they can be used in preparation of anticoccidial drug.

METHOD OF CONVERTING ALCOHOL TO HALIDE

The present invention relates to a method of converting an alcohol into a corresponding halide. This method comprises reacting the alcohol with an optionally substituted aromatic carboxylic acid halide in presence of an N-substituted formamide to replace a hydroxyl group of the alcohol by a halogen atom. The present invention also relates to a method of converting an alcohol into a corresponding substitution product. The second method comprises: (a) performing the method of the invention of converting an alcohol into the corresponding halide; and (b) reacting the corresponding halide with a nucleophile to convert the halide into the nucleophilic substitution product.

Formamides as Lewis Base Catalysts in SNReactions—Efficient Transformation of Alcohols into Chlorides, Amines, and Ethers

A simple formamide catalyst facilitates the efficient transformation of alcohols into alkyl chlorides with benzoyl chloride as the sole reagent. These nucleophilic substitutions proceed through iminium-activated alcohols as intermediates. The novel method, which can be even performed under solvent-free conditions, is distinguished by an excellent functional group tolerance, scalability (>100 g) and waste-balance (E-factor down to 2). Chiral substrates are converted with excellent levels of stereochemical inversion (99 %→≥95 % ee). In a practical one-pot procedure, the primary formed chlorides can be further transformed into amines, azides, ethers, sulfides, and nitriles. The value of the method was demonstrated in straightforward syntheses of the drugs rac-Clopidogrel and S-Fendiline.

CYCLOHEXANE ANALOGUES AS GPR119 AGONISTS

This invention relates to a series of substituted cyclohexane containing analogues which are agonists of GPR119 intended to treat metabolic diseases mediated by GPR119 including Type I & II diabetes mellitus. Diabetes mellitus is an ever-increasing threat to human health causing various complications (blindness, kidney failure, neuropathy, heart attack, stroke, etc.). Recently it was found that activation of GPR119 which is highly expressed in pancreatic beta cells causes glucose dependent insulin secretion and GLP-1 release. Many pharmaceuticals are currently developing GPR119 agonists and herein we disclose alternative GPR119 agonists. Our invention describes GPR119 agonists having structural Formula (I), pharmaceutically acceptable salt or solvate of Formula (I), isomer or prodrug of Formula (I), and combination therapy of Formula (I) with other anti-diabetic drugs like DPP-IV inhibitors and/or insulin sensitizers.

2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS

The invention relates to 2-thio-substituted imidazole derivatives of formula (I), wherein the radicals R1, R2, R3 and m have the meanings as cited in the description. The inventive compounds comprise an immunomodulatory action and/or an action that inhibits the release of cytokines and are thus suited for treating diseases associated with a disorder of the immune system.