4-Aminomethyl-cyclohexanecarboxylic acid isobutyryloxymethyl ester; hydrochloride

Base Information

• Chemical Name: 4-Aminomethyl-cyclohexanecarboxylic acid isobutyryloxymethyl ester; hydrochloride
• CAS No.: 87589-32-0
• Molecular Formula: C₁₃H₂₃NO₄*ClH
• Molecular Weight: 293.791
• Mol file: 87589-32-0.mol

Synonyms:4-Aminomethyl-cyclohexanecarboxylic acid isobutyryloxymethyl ester; hydrochloride

Chemical Property of 4-Aminomethyl-cyclohexanecarboxylic acid isobutyryloxymethyl ester; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-Aminomethyl-cyclohexanecarboxylic acid isobutyryloxymethyl ester; hydrochloride

There total 4 articles about 4-Aminomethyl-cyclohexanecarboxylic acid isobutyryloxymethyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid isobutyryloxymethyl ester (87589-31-9) → 4-Aminomethyl-cyclohexanecarboxylic acid isobutyryloxymethyl ester; hydrochloride (87589-32-0)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 ℃; for 3h; Yield given;

DOI:10.1021/jm00154a004

Reference yield:

chloromethyl isobutyrate (61644-18-6) → 4-Aminomethyl-cyclohexanecarboxylic acid isobutyryloxymethyl ester; hydrochloride (87589-32-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) tetrabutylammonium hydrogen sulfate (QHSO₄) / 2.) trichloroethylene, reflux, 3 h

2: HCl(g) / ethyl acetate / 3 h / 0 °C

With hydrogenchloride; tetra(n-butyl)ammonium hydrogensulfate; In ethyl acetate;

DOI:10.1021/jm00154a004

Reference yield:

trans-4-aminomethyl-cyclohexyl-carboxylic acid (1197-18-8) → 4-Aminomethyl-cyclohexanecarboxylic acid isobutyryloxymethyl ester; hydrochloride (87589-32-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / NaOH / H₂O; 2-methyl-propan-2-ol / 18 h / Ambient temperature

2: 1.) tetrabutylammonium hydrogen sulfate (QHSO₄) / 2.) trichloroethylene, reflux, 3 h

3: HCl(g) / ethyl acetate / 3 h / 0 °C

With hydrogenchloride; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In water; ethyl acetate; tert-butyl alcohol;

DOI:10.1021/jm00154a004

upstream raw materials:

4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid isobutyryloxymethyl ester

chloromethyl isobutyrate

trans-4-aminomethyl-cyclohexyl-carboxylic acid

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid