C₁₅H₂₁NO₅Si

Base Information

• Chemical Name: C₁₅H₂₁NO₅Si
• CAS No.: 1265279-46-6
• Molecular Formula: C₁₅H₂₁NO₅Si
• Molecular Weight: 323.421
• Mol file: 1265279-46-6.mol

Synonyms:C₁₅H₂₁NO₅Si

Chemical Property of C₁₅H₂₁NO₅Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of C₁₅H₂₁NO₅Si

There total 1 articles about C₁₅H₂₁NO₅Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-(trimethylsilyl)-ethyl 3-amino-2,4-dihydroxybenzoate (1020070-44-3) + acrylic acid (79-10-7) → C15H21NO5Si (1265279-46-6)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide; at 23 ℃; for 16h; Inert atmosphere;

DOI:10.1002/ejoc.201001281

Reference yield: 42.0%

(2S,4aS,8S,8aR)-8-allyl-8-methyl-3-methylene-1,2,3,4,8,8a-hexahydro-7H-2,4a-ethanonaphthalen-7-one + C15H21NO5Si (1265279-46-6) → C30H39NO6Si (1265279-47-7)

Guidance literature:

With Hoveyda-Grubbs catalyst second generation; In benzene; at 70 ℃; for 1.17h; Inert atmosphere;

DOI:10.1002/ejoc.201001281

Reference yield:

(2S,4aS,8S,8aR)-8-allyl-8-methyl-3-methylene-1,2,3,4,8,8a-hexahydro-7H-2,4a-ethanonaphthalen-7-one + C15H21NO5Si (1265279-46-6) → C25H27NO6 (1265278-80-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Hoveyda-Grubbs catalyst second generation / benzene / 1.17 h / 70 °C / Inert atmosphere

2: tris(dimethylamino)sulfonium trimethylsilyldifluoride; HATU / N,N-dimethyl-formamide / 1.33 h / 23 - 40 °C / Inert atmosphere

With Hoveyda-Grubbs catalyst second generation; tris(dimethylamino)sulfonium trimethylsilyldifluoride; HATU; In N,N-dimethyl-formamide; benzene;

DOI:10.1002/ejoc.201001281

upstream raw materials:

2-(trimethylsilyl)-ethyl 3-amino-2,4-dihydroxybenzoate

acrylic acid

Downstream raw materials:

C₃₀H₃₉NO₆Si

C₂₅H₂₇NO₆