{3-[6-(4-methoxy-3-trifluoromethylphenyl)quinazolin-4-yl]phenyl}-(4-methylpiperazin-1-yl)methanone trifluoroacetate

Base Information

Chemical Name:{3-[6-(4-methoxy-3-trifluoromethylphenyl)quinazolin-4-yl]phenyl}-(4-methylpiperazin-1-yl)methanone trifluoroacetate
CAS No.:1443776-38-2
Molecular Formula:C₂HF₃O₂*C₂₈H₂₅F₃N₄O₂
Molecular Weight:620.551
Hs Code.:

Synonyms:{3-[6-(4-methoxy-3-trifluoromethylphenyl)quinazolin-4-yl]phenyl}-(4-methylpiperazin-1-yl)methanone trifluoroacetate

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Chemical Property of {3-[6-(4-methoxy-3-trifluoromethylphenyl)quinazolin-4-yl]phenyl}-(4-methylpiperazin-1-yl)methanone trifluoroacetate

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Technology Process of {3-[6-(4-methoxy-3-trifluoromethylphenyl)quinazolin-4-yl]phenyl}-(4-methylpiperazin-1-yl)methanone trifluoroacetate

There total 6 articles about {3-[6-(4-methoxy-3-trifluoromethylphenyl)quinazolin-4-yl]phenyl}-(4-methylpiperazin-1-yl)methanone trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1445019-24-8
2-[4-methoxy-3-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1431542-30-1
[3-(6-bromo-quinazolin-4-yl)-phenyl]-(4-methyl-piperazin-1-yl)-methanone

: 76-05-1
trifluoroacetic acid

: 1443776-38-2
{3-[6-(4-methoxy-3-trifluoromethylphenyl)quinazolin-4-yl]phenyl}-(4-methylpiperazin-1-yl)methanone trifluoroacetate

Guidance literature:: 2-[4-methoxy-3-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; [3-(6-bromo-quinazolin-4-yl)-phenyl]-(4-methyl-piperazin-1-yl)-methanone; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 140 ℃; for 0.166667h; Inert atmosphere; Microwave irradiation;

trifluoroacetic acid;

Reference yield:

: 1431542-29-8
3-(6-bromo-quinazolin-4-yl)-benzoic acid ethyl ester

: 1443776-38-2
{3-[6-(4-methoxy-3-trifluoromethylphenyl)quinazolin-4-yl]phenyl}-(4-methylpiperazin-1-yl)methanone trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 3 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 0.08 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 0.17 h / 140 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; water; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1431542-28-7
3-(6-bromo-quinazolin-4-yl)-benzoic acid

: 1443776-38-2
{3-[6-(4-methoxy-3-trifluoromethylphenyl)quinazolin-4-yl]phenyl}-(4-methylpiperazin-1-yl)methanone trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 0.08 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 0.17 h / 140 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;