(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{3-[(tert-butoxycarbonyl)amino]propoxy}benzyl)-2-hydroxypropylcarbamate

Base Information

Chemical Name:(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{3-[(tert-butoxycarbonyl)amino]propoxy}benzyl)-2-hydroxypropylcarbamate
CAS No.:313680-02-3
Molecular Formula:C₃₆H₅₁N₃O₁₂S
Molecular Weight:749.88
Hs Code.:

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{3-[(tert-butoxycarbonyl)amino]propoxy}benzyl)-2-hydroxypropylcarbamate

Synonyms:(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{3-[(tert-butoxycarbonyl)amino]propoxy}benzyl)-2-hydroxypropylcarbamate

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Chemical Property of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{3-[(tert-butoxycarbonyl)amino]propoxy}benzyl)-2-hydroxypropylcarbamate

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Technology Process of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{3-[(tert-butoxycarbonyl)amino]propoxy}benzyl)-2-hydroxypropylcarbamate

There total 12 articles about (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{3-[(tert-butoxycarbonyl)amino]propoxy}benzyl)-2-hydroxypropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 313679-57-1
(3R,3AS,6AR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-2-hydroxy-1-(4-hydroxybenzyl)propylcarbamate

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 313680-02-3
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{3-[(tert-butoxycarbonyl)amino]propoxy}benzyl)-2-hydroxypropylcarbamate

Guidance literature:: With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In dichloromethane;
DOI:10.1016/j.bmcl.2005.05.129

Reference yield:

: 162536-84-7
tert-butyl (1S)-2-[4-(benzyloxy)phenyl]-1-[(2S)-oxiranyl]ethylcarbamate

: 313680-02-3
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{3-[(tert-butoxycarbonyl)amino]propoxy}benzyl)-2-hydroxypropylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: propan-2-ol / Heating

2: DIEA / CH₂Cl₂

3: 100 percent / TFA / CH₂Cl₂

4: 96 percent / DIEA / acetonitrile

5: 98 percent / H₂ / Pd/C / tetrahydrofuran

6: di-t-butylazodicarboxylate; Ph₃P / CH₂Cl₂

With di-tert-butyl-diazodicarboxylate; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; isopropyl alcohol; acetonitrile; 6: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2005.05.129

Reference yield:

: 174801-33-3,1059189-63-7
(2S,3S)-N-tert-butoxycarbonyl-3-amino-4-(4-benzyloxyphenyl)-1-chloro-2-hydroxybutane

: 313680-02-3
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{3-[(tert-butoxycarbonyl)amino]propoxy}benzyl)-2-hydroxypropylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1: KOH / ethanol

2: propan-2-ol / Heating

3: DIEA / CH₂Cl₂

4: 100 percent / TFA / CH₂Cl₂

5: 96 percent / DIEA / acetonitrile

6: 98 percent / H₂ / Pd/C / tetrahydrofuran

7: di-t-butylazodicarboxylate; Ph₃P / CH₂Cl₂

With potassium hydroxide; di-tert-butyl-diazodicarboxylate; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol; acetonitrile; 7: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2005.05.129