3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propane

Base Information

• Chemical Name: 3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propane
• CAS No.: 186387-85-9
• Molecular Formula: C₂₄H₃₁F₃N₂O₂
• Molecular Weight: 436.518

Synonyms:3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propane

Chemical Property of 3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propane

Chemical Property:

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Technology Process of 3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propane

There total 3 articles about 3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-1-propanone (186387-84-8) → 3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propane (186387-85-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.1016/S0960-894X(03)00305-6

Reference yield:

3-(benzyloxy)-2,2-dimethylpropanoyl chloride (36881-15-9) → 3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propane (186387-85-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / benzene / 0 °C

2: 96 percent / LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; benzene;

DOI:10.1016/S0960-894X(03)00305-6

Reference yield:

1-[2-(2,2,2-trifluoroethoxy)-phenyl]-piperazine (178671-99-3) → 3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propane (186387-85-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / benzene / 0 °C

2: 96 percent / LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; benzene;

DOI:10.1016/S0960-894X(03)00305-6

upstream raw materials:

3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-1-propanone

3-(benzyloxy)-2,2-dimethylpropanoyl chloride

1-[2-(2,2,2-trifluoroethoxy)-phenyl]-piperazine

Downstream raw materials:

toluene-4-sulfonic acid 2,2-dimethyl-3-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-yl}-propyl ester

1-benzyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-2,2-dimethylpropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

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