3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-1-propanone

Base Information

• Chemical Name: 3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-1-propanone
• CAS No.: 186387-84-8
• Molecular Formula: C₂₄H₂₉F₃N₂O₃
• Molecular Weight: 450.501

Synonyms:3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-1-propanone

Chemical Property of 3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-1-propanone

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Technology Process of 3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-1-propanone

There total 2 articles about 3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-(benzyloxy)-2,2-dimethylpropanoyl chloride (36881-15-9) + 1-[2-(2,2,2-trifluoroethoxy)-phenyl]-piperazine (178671-99-3) → 3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-1-propanone (186387-84-8)

Guidance literature:

In benzene; at 0 ℃;

DOI:10.1016/S0960-894X(03)00305-6

Reference yield:

oxalyl dichloride (79-37-8) + 3-(benzyloxy)-2,2-dimethylpropionic acid (36881-14-8) + 1-[2-(2,2,2-trifluoroethoxy)-phenyl]-piperazine (178671-99-3) → 3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-1-propanone (186387-84-8)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; benzene;

Reference yield: 96.0%

3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-1-propanone (186387-84-8) → 3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propane (186387-85-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.1016/S0960-894X(03)00305-6

upstream raw materials:

3-(benzyloxy)-2,2-dimethylpropanoyl chloride

1-[2-(2,2,2-trifluoroethoxy)-phenyl]-piperazine

oxalyl dichloride

3-(benzyloxy)-2,2-dimethylpropionic acid

Downstream raw materials:

3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propane

2,2-dimethyl-3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-1-propanol

toluene-4-sulfonic acid 2,2-dimethyl-3-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-yl}-propyl ester

1-benzyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-2,2-dimethylpropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

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