5-[4-bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-yl]-2-chloro-4-fluorobenzoic acid

Base Information

Chemical Name:5-[4-bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-yl]-2-chloro-4-fluorobenzoic acid
CAS No.:174514-08-0
Molecular Formula:C₁₂H₆BrClF₄N₂O₂
Molecular Weight:401.542
Hs Code.:

Synonyms:5-[4-bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-yl]-2-chloro-4-fluorobenzoic acid

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Chemical Property of 5-[4-bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-yl]-2-chloro-4-fluorobenzoic acid

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Technology Process of 5-[4-bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-yl]-2-chloro-4-fluorobenzoic acid

There total 6 articles about 5-[4-bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-yl]-2-chloro-4-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 177489-17-7
2-chloro-4-fluoro-5-(1-methyl-5-trifluoromethyl-1H-pyrazol-3-yl)-benzoic acid

: 174514-08-0
5-[4-bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-yl]-2-chloro-4-fluorobenzoic acid

Guidance literature:: With bromine; In toluene; at 75 ℃; for 36h;
DOI:10.1002/1099-1344(200006)43:7<645::AID-JLCR349>3.0.CO;2-6

Reference yield:

: 452-73-3
2-chloro-4-fluorotoluene

: 174514-08-0
5-[4-bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-yl]-2-chloro-4-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / AlCl₃ / CH₂Cl₂ / 3 h / 20 °C

2: 87 percent / NaOMe / methanol / 4.5 h / Heating

3: 99 percent / H₂NNH₂ / 3 h / Heating

4: 74 percent / toluene / 6 h / Heating

5: glacial AcOH; cobalt acetate tetrahydrate; manganese acetate tetrahydrate / 24 h / 105 °C

6: 0.865 g / Br₂ / toluene / 36 h / 75 °C

With aluminium trichloride; bromine; sodium methylate; cobalt(II) acetate; manganese(II) acetate; acetic acid; hydrazine; In methanol; dichloromethane; toluene; 1: Acylation / 2: Condensation / 3: Cyclization / 4: Methylation / 5: Oxidation / 6: Bromination;
DOI:10.1002/1099-1344(200006)43:7<645::AID-JLCR349>3.0.CO;2-6

Reference yield:

: 177211-26-6
1-(4-chloro-2-fluoro-5-methylphenyl [ring-14C(U)])-ethanone

: 174514-08-0
5-[4-bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-yl]-2-chloro-4-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / NaOMe / methanol / 4.5 h / Heating

2: 99 percent / H₂NNH₂ / 3 h / Heating

3: 74 percent / toluene / 6 h / Heating

4: glacial AcOH; cobalt acetate tetrahydrate; manganese acetate tetrahydrate / 24 h / 105 °C

5: 0.865 g / Br₂ / toluene / 36 h / 75 °C

With bromine; sodium methylate; cobalt(II) acetate; manganese(II) acetate; acetic acid; hydrazine; In methanol; toluene; 1: Condensation / 2: Cyclization / 3: Methylation / 4: Oxidation / 5: Bromination;
DOI:10.1002/1099-1344(200006)43:7<645::AID-JLCR349>3.0.CO;2-6