6-methyl-2-oxo-3-[(2-phenylethyl)amino]-1(2H)-pyrazineacetic acid ethyl ester

Base Information

Chemical Name:6-methyl-2-oxo-3-[(2-phenylethyl)amino]-1(2H)-pyrazineacetic acid ethyl ester
CAS No.:298704-30-0
Molecular Formula:C₁₇H₂₁N₃O₃
Molecular Weight:315.372
Hs Code.:

Synonyms:6-methyl-2-oxo-3-[(2-phenylethyl)amino]-1(2H)-pyrazineacetic acid ethyl ester

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Chemical Property of 6-methyl-2-oxo-3-[(2-phenylethyl)amino]-1(2H)-pyrazineacetic acid ethyl ester

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Technology Process of 6-methyl-2-oxo-3-[(2-phenylethyl)amino]-1(2H)-pyrazineacetic acid ethyl ester

There total 8 articles about 6-methyl-2-oxo-3-[(2-phenylethyl)amino]-1(2H)-pyrazineacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.8%

: 64-04-0
phenethylamine

: 221136-66-9
3-bromo-1-(ethoxycarbonylmethyl)-6-methylpyrazinone

: 298704-30-0
6-methyl-2-oxo-3-[(2-phenylethyl)amino]-1(2H)-pyrazineacetic acid ethyl ester

: 2-(6-methyl-2-oxo-3-phenethylamino-2H-pyrazin-1-yl)-N-phenethyl-acetamide

Guidance literature:: In ethanol; for 19.25h; Heating;
DOI:10.1080/00397910008086927

Reference yield: 82.0%

: 64-04-0
phenethylamine

: 221136-66-9
3-bromo-1-(ethoxycarbonylmethyl)-6-methylpyrazinone

: 298704-30-0
6-methyl-2-oxo-3-[(2-phenylethyl)amino]-1(2H)-pyrazineacetic acid ethyl ester

Guidance literature:: In ethanol; toluene; at 125 ℃; for 18h; Sealed tube;

Reference yield:

: 29655-79-6
[(2-ethoxy-2-oxoethyl)amino]oxoacetic acid ethyl ester

: 298704-30-0
6-methyl-2-oxo-3-[(2-phenylethyl)amino]-1(2H)-pyrazineacetic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / ethanol / Heating

2: 62 percent / RuCl₃; aq. NaBrO₃

3: TFAA / 80 °C

4: POBr₃; aq. NH₃ / Heating

5: Et₃N / dioxane / 65 - 100 °C

With ruthenium trichloride; ammonium hydroxide; sodium bromate; triethylamine; trifluoroacetic anhydride; phosphorus(V) oxybromide; In 1,4-dioxane; ethanol;
DOI:10.1016/S0960-894X(02)00129-4