2-[4-(2-oxa-4-hydroxybutyl)phenyl]-1-(2,2,6,6,-tetramethyl-1-piperidinyloxy)ethyl 2-bromo-2-methylpropionate

Base Information

• Chemical Name: 2-[4-(2-oxa-4-hydroxybutyl)phenyl]-1-(2,2,6,6,-tetramethyl-1-piperidinyloxy)ethyl 2-bromo-2-methylpropionate
• CAS No.: 697248-59-2
• Molecular Formula: C₂₄H₃₈BrNO₅
• Molecular Weight: 500.473
• Mol file: 697248-59-2.mol

Synonyms:2-[4-(2-oxa-4-hydroxybutyl)phenyl]-1-(2,2,6,6,-tetramethyl-1-piperidinyloxy)ethyl 2-bromo-2-methylpropionate

Chemical Property of 2-[4-(2-oxa-4-hydroxybutyl)phenyl]-1-(2,2,6,6,-tetramethyl-1-piperidinyloxy)ethyl 2-bromo-2-methylpropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(2-oxa-4-hydroxybutyl)phenyl]-1-(2,2,6,6,-tetramethyl-1-piperidinyloxy)ethyl 2-bromo-2-methylpropionate

There total 5 articles about 2-[4-(2-oxa-4-hydroxybutyl)phenyl]-1-(2,2,6,6,-tetramethyl-1-piperidinyloxy)ethyl 2-bromo-2-methylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.8%

2-bromo-2-methyl-propionic acid 2-{4-[2-(tetrahydro-pyran-2-yloxy)-ethoxymethyl]-phenyl}-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-ethyl ester (697248-57-0) → 2-[4-(2-oxa-4-hydroxybutyl)phenyl]-1-(2,2,6,6,-tetramethyl-1-piperidinyloxy)ethyl 2-bromo-2-methylpropionate (697248-59-2)

Guidance literature:

With Amberlist 15; In methanol; at 35 ℃;

DOI:10.1021/ma036010c

Reference yield:

2-{4-[2-(tetrahydro-pyran-2-yloxy)-ethoxymethyl]-phenyl}-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-ethanol (697248-56-9) → 2-[4-(2-oxa-4-hydroxybutyl)phenyl]-1-(2,2,6,6,-tetramethyl-1-piperidinyloxy)ethyl 2-bromo-2-methylpropionate (697248-59-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 79.2 percent / triethylamine / CH₂Cl₂ / 8 h / 20 °C

2: 65.8 percent / Amberlist 15 / methanol / 35 °C

With Amberlist 15; triethylamine; In methanol; dichloromethane;

DOI:10.1021/ma036010c

Reference yield:

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3) → 2-[4-(2-oxa-4-hydroxybutyl)phenyl]-1-(2,2,6,6,-tetramethyl-1-piperidinyloxy)ethyl 2-bromo-2-methylpropionate (697248-59-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 10.1 percent / 20 h / 80 °C

2: 76.8 percent / NaH / tetrahydrofuran / 20 °C

3: 79.2 percent / triethylamine / CH₂Cl₂ / 8 h / 20 °C

4: 65.8 percent / Amberlist 15 / methanol / 35 °C

With Amberlist 15; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/ma036010c

upstream raw materials:

2-bromo-2-methyl-propionic acid 2-{4-[2-(tetrahydro-pyran-2-yloxy)-ethoxymethyl]-phenyl}-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-ethyl ester

2-{4-[2-(tetrahydro-pyran-2-yloxy)-ethoxymethyl]-phenyl}-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-ethanol

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

4-Vinylbenzyl chloride