Technology Process of (R)-tert-butyl 2-(tetrahydro-2H-pyran-4-yl)pyrrolidine-1-carboxylate
There total 1 articles about (R)-tert-butyl 2-(tetrahydro-2H-pyran-4-yl)pyrrolidine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl pyrrolidine-1-carboxylate;
With
N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium;
In
diethyl ether; cyclohexane;
at -78 ℃;
for 3.5h;
Inert atmosphere;
With
zinc(II) iodide;
In
tetrahydrofuran; diethyl ether; cyclohexane;
at -78 - 20 ℃;
for 1.5h;
Cooling with acetone-dry ice;
Inert atmosphere;
4-iodotetrahydropyran;
With
(1,2-dimethoxyethane)dichloronickel(II); (1S,2S)-N,N’-dimethyl-1,2-di(naphthalen-1-yl)ethane-1,2-diamine;
In
tetrahydrofuran; diethyl ether; cyclohexane;
at 20 ℃;
for 60h;
Reagent/catalyst;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ja4054114
- Guidance literature:
-
Multi-step reaction with 2 steps
1: trifluoroacetic acid / dichloromethane / 1 h
2: triethylamine / dichloromethane / 10 h
With
triethylamine; trifluoroacetic acid;
In
dichloromethane;
DOI:10.1021/ja4054114
