Technology Process of trifluoromethanesulfonic acid 2-cyano-6-pyridin-4-yl-phenyl ester
There total 6 articles about trifluoromethanesulfonic acid 2-cyano-6-pyridin-4-yl-phenyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine; dmap;
at 20 ℃;
for 24h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-Bromosuccinimide; diisopropylamine / toluene / 6 h / 70 °C / Inert atmosphere
2: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C
3: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 17 h / Inert atmosphere; Reflux
4: potassium carbonate; thiophenol / 1-methyl-pyrrolidin-2-one / 0.5 h / 190 °C
5: pyridine; dmap / 24 h / 20 °C / Inert atmosphere
With
pyridine; dmap; N-Bromosuccinimide; sodium carbonate; potassium carbonate; thiophenol; diisopropylamine;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 17 h / Inert atmosphere; Reflux
2: potassium carbonate; thiophenol / 1-methyl-pyrrolidin-2-one / 0.5 h / 190 °C
3: pyridine; dmap / 24 h / 20 °C / Inert atmosphere
With
pyridine; dmap; sodium carbonate; potassium carbonate; thiophenol;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one; water;
