3-BROMO-2-METHOXYBENZONITRILE

Base Information

• Chemical Name: 3-BROMO-2-METHOXYBENZONITRILE
• CAS No.: 874472-98-7
• Molecular Formula: C8H6 Br N O
• Molecular Weight: 212.046
• Hs Code.: 2926907090
• Mol file: 874472-98-7.mol

Synonyms:3-Bromo-2-methoxybenzonitrile

Chemical Property of 3-BROMO-2-METHOXYBENZONITRILE

Chemical Property:

• Melting Point: 75-78 °C
• PSA: 33.02000
• LogP: 2.32938
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-2-methoxybenzonitrile ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-2-METHOXYBENZONITRILE

There total 3 articles about 3-BROMO-2-METHOXYBENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.05%

3-bromo-2-hydroxybenzonitrile (13073-28-4) + methyl iodide (74-88-4) → 3-bromo-2-methoxybenzonitrile (874472-98-7)

Guidance literature:

3-bromo-2-hydroxybenzonitrile; With potassium carbonate; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

methyl iodide; In N,N-dimethyl-formamide; at 60 ℃; for 2h;

Reference yield:

phenyl cyanate (1122-85-6) + methyl iodide (74-88-4) → 3-bromo-2-methoxybenzonitrile (874472-98-7)

Guidance literature:

phenyl cyanate; With N-Bromosuccinimide; N-ethyl-N,N-diisopropylamine; In toluene; at 70 ℃; for 2h;

methyl iodide; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Reagent/catalyst;

Reference yield:

salicylonitrile (611-20-1) → 3-bromo-2-methoxybenzonitrile (874472-98-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; diisopropylamine / toluene / 6 h / 70 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

With N-Bromosuccinimide; potassium carbonate; diisopropylamine; In N,N-dimethyl-formamide; toluene;

upstream raw materials:

3-bromo-2-hydroxybenzonitrile

methyl iodide

phenyl cyanate

salicylonitrile

Downstream raw materials:

2-methoxy-3-(4, 4,5,5-tetramethyl-1,3, 2-dioxaborolan-2-yl)benzonitrile

(+/-)-5-chloro-6-(3-cyano-2-methoxyphenyl)-1,2,3,4-tetrahydro-2,2,4,8-tetramethylquinoline

2-methoxy-3-pyridin-4-yl-benzonitrile

3-bromo-N-hydroxy-2-(methyloxy)benzenecarboximidamide