N-(3-(dimethylamino)propyl)-2,4-dimethyl-5-((6-((3-(3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamido)phenyl)amino)-2-oxoindolin-3-ylidene)methyl)-1H-pyrrole-3-carboxamide

Base Information

Chemical Name:N-(3-(dimethylamino)propyl)-2,4-dimethyl-5-((6-((3-(3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamido)phenyl)amino)-2-oxoindolin-3-ylidene)methyl)-1H-pyrrole-3-carboxamide
CAS No.:887398-87-0
Molecular Formula:C₄₀H₄₅F₃N₈O₃
Molecular Weight:742.844
Hs Code.:

N-(3-(dimethylamino)propyl)-2,4-dimethyl-5-((6-((3-(3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamido)phenyl)amino)-2-oxoindolin-3-ylidene)methyl)-1H-pyrrole-3-carboxamide

Synonyms:N-(3-(dimethylamino)propyl)-2,4-dimethyl-5-((6-((3-(3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamido)phenyl)amino)-2-oxoindolin-3-ylidene)methyl)-1H-pyrrole-3-carboxamide

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Chemical Property of N-(3-(dimethylamino)propyl)-2,4-dimethyl-5-((6-((3-(3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamido)phenyl)amino)-2-oxoindolin-3-ylidene)methyl)-1H-pyrrole-3-carboxamide

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Technology Process of N-(3-(dimethylamino)propyl)-2,4-dimethyl-5-((6-((3-(3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamido)phenyl)amino)-2-oxoindolin-3-ylidene)methyl)-1H-pyrrole-3-carboxamide

There total 5 articles about N-(3-(dimethylamino)propyl)-2,4-dimethyl-5-((6-((3-(3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamido)phenyl)amino)-2-oxoindolin-3-ylidene)methyl)-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 887398-70-1
2,4-dimethyl-5-((6-((3-(3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamido)phenyl)amino)-2-oxoindolin-3-ylidene)methyl)-1H-pyrrole-3-carboxylic acid

: 109-55-7
1-amino-3-(dimethylamino)propane

: 887398-87-0
N-(3-(dimethylamino)propyl)-2,4-dimethyl-5-((6-((3-(3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamido)phenyl)amino)-2-oxoindolin-3-ylidene)methyl)-1H-pyrrole-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/ml200261d

Reference yield:

: 6127-11-3
(4-bromo-2-nitrophenyl)acetic acid

: 887398-87-0
N-(3-(dimethylamino)propyl)-2,4-dimethyl-5-((6-((3-(3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamido)phenyl)amino)-2-oxoindolin-3-ylidene)methyl)-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid / 80 °C

2: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 110 °C

3: palladium 10% on activated carbon; hydrogen / acetic acid / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

5: piperidine / ethanol / 2 h / 80 °C

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With piperidine; sulfuric acid; palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/ml200261d

Reference yield:

: 1033771-61-7
ethyl 2-(2-nitro-4-(3-nitrophenylamino)phenyl)acetate

: 887398-87-0
N-(3-(dimethylamino)propyl)-2,4-dimethyl-5-((6-((3-(3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamido)phenyl)amino)-2-oxoindolin-3-ylidene)methyl)-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / acetic acid / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

3: piperidine / ethanol / 2 h / 80 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With piperidine; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/ml200261d