6127-11-3

Basic information

• Product Name: (4-BROMO-2-NITRO-PHENYL)-ACETIC ACID
• Synonyms: 2-(4-BROMO-2-NITROPHENYL)ACETIC ACID;(4-BROMO-2-NITRO-PHENYL)-ACETIC ACID;4-Bromo-2-nitrophenylacetic acid 97%;(2-Nitro-4-bromophenyl)acetic acid;Benzeneacetic acid,4-broMo-2-nitro-
• CAS NO: 6127-11-3
• Molecular Formula: C₈H₆BrNO₄
• Molecular Weight: 260.04
• Product Categories: blocks;Bromides;Carboxes
• Mol File: 6127-11-3.mol
• Article Data: 20

Chemical Properties

• Melting Point: 156-160
• Boiling Point: 392 ºC at 760 mmHg
• Flash Point: 190.9 ºC
• Appearance: /
• Density: 1.794
• Vapor Pressure: 7.56E-07mmHg at 25°C
• Refractive Index: 1.63
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.81±0.10(Predicted)
• CAS DataBase Reference: (4-BROMO-2-NITRO-PHENYL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4-BROMO-2-NITRO-PHENYL)-ACETIC ACID(6127-11-3)
• EPA Substance Registry System: (4-BROMO-2-NITRO-PHENYL)-ACETIC ACID(6127-11-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 6127-11-3(Hazardous Substances Data)

Usage

Uses

4-Bromo-2-nitrophenylacetic acid is used in the preparation and structure-activity relations of GNF-5837 derivatives, which are selective TRK inhibitors with efficacy in rodent cancer tumor models

InChI:InChI=1/C8H6BrNO4/c9-6-2-1-5(3-8(11)12)7(4-6)10(13)14/h1-2,4H,3H2,(H,11,12)

Upstream product

• 100487-82-9 4-bromo-2-nitro-benzoic acid methyl ester 
• 364-73-8 4-Bromo-1-fluoro-2-nitrobenzene 
• 199328-34-2 diethyl 2-(4-bromo-2-nitrophenyl)malonate 
• 100487-81-8 2-(4-bromo-2-nitro-phenyl)malonic acid dimethyl ester 
• 119-32-4 4-Methyl-3-nitroanilin 
• 442521-40-6 ethyl 3-(4-bromo-2-nitrophenyl)-2-oxopropanoate 
• 60956-26-5 4-bromo-2-nitrotoluene 
• 95-92-1 oxalic acid diethyl ester 
• 99365-39-6 3-(4-bromo-2-nitrophenyl)-2-oxopropanoic acid 

Downstream Products

• 1190866-02-4 6’-bromospiro[cyclohexane-1,3’-indolin]-2’-one 
• 364344-58-1 ethyl 4-(4-bromo-2-nitrophenyl)-3-oxobutanoate 
• 99365-40-9 6-bromo-2,3-dihydro-1H-indole-2-one 
• 100487-82-9 4-bromo-2-nitro-benzoic acid methyl ester 
• 90178-90-8 6-(2-Imidazolin-2-yl)-2-<4-<4-(2-imidazolin-2-yl)phenoxy>phenyl>indol-dihydrochlorid 
• 55453-00-4 2-<4-(4-Amidinophenoxy)phenyl>indol-6-carboxamidin-dihydrochlorid 
• 55368-13-3 2-<4-(4-Cyanphenoxy)phenyl>indol-6-carbonitril 
• 90178-61-3 6-Brom-2-<4-(4-bromphenoxy)phenyl>indol 
• 99365-41-0 3-hydroxymethylene-6-bromooxindole 

Relevant articles and documents

Discovery of GNF-5837, a selective TRK inhibitor with efficacy in rodent cancer tumor models

Neurotrophins and their receptors (TRKs) play key roles in the development of the nervous system and the maintenance of the neural network. Accumulating evidence points to their role in malignant transformations, chemotaxis, metastasis, and survival signaling and may contribute to the pathogenesis of a variety of tumors of both neural and non-neural origin. By screening the GNF kinase collection, a series of novel oxindole inhibitors of TRKs were identified. Optimization led to the identification of GNF-5837 (22), a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF. The properties of 22 make it a good tool for the elucidation of TRK biology in cancer and other nononcology indications.

New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors

This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.

COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS

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