Technology Process of N,N-dibenzyl-3-methylbutan-2-amine
There total 5 articles about N,N-dibenzyl-3-methylbutan-2-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N,N-dibenzylacetamide;
With
2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride;
In
dichloromethane;
at -78 ℃;
for 0.75h;
isopropylmagnesium bromide;
In
diethyl ether; dichloromethane;
at -78 - 20 ℃;
for 1h;
With
lithium aluminium tetrahydride;
In
diethyl ether; dichloromethane;
at 20 ℃;
for 1h;
DOI:10.1002/chem.201002054
- Guidance literature:
-
2-methyl-N,N-bis(phenylmethyl)-propionamide;
With
2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride;
In
dichloromethane;
at -78 - 0 ℃;
for 1h;
Inert atmosphere;
halo(methyl)magnesium;
In
diethyl ether; dichloromethane;
at -78 - 20 ℃;
for 1h;
Inert atmosphere;
With
lithium aluminium tetrahydride;
In
diethyl ether; dichloromethane;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/jo4007656
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 75 percent / diethyl ether; tetrahydrofuran / 1 h / Heating
2: benzene / Heating; Dean-Stark trap
3: diethyl ether; benzene / 4 h / Heating
In
tetrahydrofuran; diethyl ether; benzene;
