t-butyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-bromobenzoate

Base Information

Chemical Name:t-butyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-bromobenzoate
CAS No.:1424279-66-2
Molecular Formula:C₂₁H₁₇BrCl₂F₃NO₃
Molecular Weight:539.176
Hs Code.:

Synonyms:t-butyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-bromobenzoate

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Chemical Property of t-butyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-bromobenzoate

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Technology Process of t-butyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-bromobenzoate

There total 2 articles about t-butyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-bromobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.7%

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 1424279-64-0
tert-butyl 4-hydroxyiminomethyl-2-bromobenzoate

: 1424279-66-2
t-butyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-bromobenzoate

Guidance literature:: tert-butyl 4-hydroxyiminomethyl-2-bromobenzoate; With N-chloro-succinimide; In N,N-dimethyl-formamide; at 50 ℃; for 3h; Inert atmosphere;

1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 1424279-65-1
t-butyl 4-formyl-2-bromobenzoate

: 1424279-66-2
t-butyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-bromobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium acetate; hydroxylamine hydrochloride / isopropyl alcohol; water / 3 h / 10 - 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere

2.2: 16 h / 20 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; In water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield: 74.0%

: 97-94-9
triethyl borane

: 1424279-66-2
t-butyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-bromobenzoate

: 1424279-67-3
t-butyl 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In tetrahydrofuran; at 75 ℃; for 4h;