1-(3-carboxy-4-fluorobenzyl)-8-hydroxy-4-oxo-1,4-dihydrocinnolin-1-ium chloride

Base Information

Chemical Name:1-(3-carboxy-4-fluorobenzyl)-8-hydroxy-4-oxo-1,4-dihydrocinnolin-1-ium chloride
CAS No.:1126475-37-3
Molecular Formula:C₁₆H₁₁FN₂O₄*ClH
Molecular Weight:350.734
Hs Code.:

Synonyms:1-(3-carboxy-4-fluorobenzyl)-8-hydroxy-4-oxo-1,4-dihydrocinnolin-1-ium chloride

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Chemical Property of 1-(3-carboxy-4-fluorobenzyl)-8-hydroxy-4-oxo-1,4-dihydrocinnolin-1-ium chloride

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Technology Process of 1-(3-carboxy-4-fluorobenzyl)-8-hydroxy-4-oxo-1,4-dihydrocinnolin-1-ium chloride

There total 5 articles about 1-(3-carboxy-4-fluorobenzyl)-8-hydroxy-4-oxo-1,4-dihydrocinnolin-1-ium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1126475-34-0
1-(3-carboxy-4-fluorobenzyl)-8-fluoro-4-oxo-1,4-dihydrocinnolin-1-ium chloride

: 1126475-37-3
1-(3-carboxy-4-fluorobenzyl)-8-hydroxy-4-oxo-1,4-dihydrocinnolin-1-ium chloride

Guidance literature:: 1-(3-carboxy-4-fluorobenzyl)-8-fluoro-4-oxo-1,4-dihydrocinnolin-1-ium chloride; With lithium hydroxide; In water; at 160 ℃; for 0.25h; microwaves irradiation;

With hydrogenchloride; In water;

Reference yield:

: 1126475-32-8
{8-fluoro-1-[4-fluoro-3-(methoxycarbonyl)benzyl]-4-oxo-1,4-dihydrocinnolin-3-yl}(triphenyl)phosphonium bromide

: 1126475-37-3
1-(3-carboxy-4-fluorobenzyl)-8-hydroxy-4-oxo-1,4-dihydrocinnolin-1-ium chloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol / 0.25 h / 20 °C

1.2: pH 1

2.1: lithium hydroxide / water / 0.25 h / 160 °C / microwaves irradiation

With lithium hydroxide; sodium hydroxide; In methanol; water;

Reference yield:

: 825-22-9
3-fluoroanthranilic acid

: 1126475-37-3
1-(3-carboxy-4-fluorobenzyl)-8-hydroxy-4-oxo-1,4-dihydrocinnolin-1-ium chloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 2 h / Heating / reflux

2.1: sodium amide / toluene / 3 h / 20 °C

2.2: 3.5 h / 0 - 50 °C

3.1: hydrogenchloride; isopentyl nitrite / methanol / 0.25 - 0.5 h / 0 °C

3.2: 20 °C / pH 9

4.1: acetonitrile / 1.5 h / Heating / reflux

5.1: sodium hydroxide / methanol / 0.25 h / 20 °C

5.2: pH 1

6.1: lithium hydroxide / water / 0.25 h / 160 °C / microwaves irradiation

With hydrogenchloride; lithium hydroxide; sodium hydroxide; sodium amide; isopentyl nitrite; In methanol; water; toluene; acetonitrile;