1-(3-carboxy-4-fluorobenzyl)-8-fluoro-4-oxo-1,4-dihydrocinnolin-1-ium chloride

Base Information

Chemical Name:1-(3-carboxy-4-fluorobenzyl)-8-fluoro-4-oxo-1,4-dihydrocinnolin-1-ium chloride
CAS No.:1126475-34-0
Molecular Formula:C₁₆H₁₀F₂N₂O₃*ClH
Molecular Weight:352.725
Hs Code.:

Synonyms:1-(3-carboxy-4-fluorobenzyl)-8-fluoro-4-oxo-1,4-dihydrocinnolin-1-ium chloride

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Chemical Property of 1-(3-carboxy-4-fluorobenzyl)-8-fluoro-4-oxo-1,4-dihydrocinnolin-1-ium chloride

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Technology Process of 1-(3-carboxy-4-fluorobenzyl)-8-fluoro-4-oxo-1,4-dihydrocinnolin-1-ium chloride

There total 4 articles about 1-(3-carboxy-4-fluorobenzyl)-8-fluoro-4-oxo-1,4-dihydrocinnolin-1-ium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1126475-32-8
{8-fluoro-1-[4-fluoro-3-(methoxycarbonyl)benzyl]-4-oxo-1,4-dihydrocinnolin-3-yl}(triphenyl)phosphonium bromide

: 1126475-34-0
1-(3-carboxy-4-fluorobenzyl)-8-fluoro-4-oxo-1,4-dihydrocinnolin-1-ium chloride

Guidance literature:: {8-fluoro-1-[4-fluoro-3-(methoxycarbonyl)benzyl]-4-oxo-1,4-dihydrocinnolin-3-yl}(triphenyl)phosphonium bromide; With sodium hydroxide; In methanol; at 20 ℃; for 0.25h;

With hydrogenchloride; In water; pH=1;

Reference yield:

: 825-22-9
3-fluoroanthranilic acid

: 1126475-34-0
1-(3-carboxy-4-fluorobenzyl)-8-fluoro-4-oxo-1,4-dihydrocinnolin-1-ium chloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / 2 h / Heating / reflux

2.1: sodium amide / toluene / 3 h / 20 °C

2.2: 3.5 h / 0 - 50 °C

3.1: hydrogenchloride; isopentyl nitrite / methanol / 0.25 - 0.5 h / 0 °C

3.2: 20 °C / pH 9

4.1: acetonitrile / 1.5 h / Heating / reflux

5.1: sodium hydroxide / methanol / 0.25 h / 20 °C

5.2: pH 1

With hydrogenchloride; sodium hydroxide; sodium amide; isopentyl nitrite; In methanol; toluene; acetonitrile;

Reference yield:

: 1126475-29-3
1-(2-amino-3-fluorophenyl)-2-(triphenylphosphoranylidene)ethanone

: 1126475-34-0
1-(3-carboxy-4-fluorobenzyl)-8-fluoro-4-oxo-1,4-dihydrocinnolin-1-ium chloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; isopentyl nitrite / methanol / 0.25 - 0.5 h / 0 °C

1.2: 20 °C / pH 9

2.1: acetonitrile / 1.5 h / Heating / reflux

3.1: sodium hydroxide / methanol / 0.25 h / 20 °C

3.2: pH 1

With hydrogenchloride; sodium hydroxide; isopentyl nitrite; In methanol; acetonitrile;