{8-fluoro-1-[4-fluoro-3-(methoxycarbonyl)benzyl]-4-oxo-1,4-dihydrocinnolin-3-yl}(triphenyl)phosphonium bromide

Base Information

Chemical Name:{8-fluoro-1-[4-fluoro-3-(methoxycarbonyl)benzyl]-4-oxo-1,4-dihydrocinnolin-3-yl}(triphenyl)phosphonium bromide
CAS No.:1126475-32-8
Molecular Formula:Br*C₃₅H₂₆F₂N₂O₃P
Molecular Weight:671.478
Hs Code.:

Synonyms:{8-fluoro-1-[4-fluoro-3-(methoxycarbonyl)benzyl]-4-oxo-1,4-dihydrocinnolin-3-yl}(triphenyl)phosphonium bromide

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Chemical Property of {8-fluoro-1-[4-fluoro-3-(methoxycarbonyl)benzyl]-4-oxo-1,4-dihydrocinnolin-3-yl}(triphenyl)phosphonium bromide

Chemical Property:

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Technology Process of {8-fluoro-1-[4-fluoro-3-(methoxycarbonyl)benzyl]-4-oxo-1,4-dihydrocinnolin-3-yl}(triphenyl)phosphonium bromide

There total 4 articles about {8-fluoro-1-[4-fluoro-3-(methoxycarbonyl)benzyl]-4-oxo-1,4-dihydrocinnolin-3-yl}(triphenyl)phosphonium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1126475-31-7
8-fluoro-3-(triphenylphosphoranylidene)cinnolin-4(3H)-one

: 709-45-5
2-fluoro-5-bromomethyl benzoic acid methyl ester

: 1126475-32-8
{8-fluoro-1-[4-fluoro-3-(methoxycarbonyl)benzyl]-4-oxo-1,4-dihydrocinnolin-3-yl}(triphenyl)phosphonium bromide

Guidance literature:: In acetonitrile; for 1.5h; Heating / reflux;

Reference yield:

: 825-22-9
3-fluoroanthranilic acid

: 1126475-32-8
{8-fluoro-1-[4-fluoro-3-(methoxycarbonyl)benzyl]-4-oxo-1,4-dihydrocinnolin-3-yl}(triphenyl)phosphonium bromide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 2 h / Heating / reflux

2.1: sodium amide / toluene / 3 h / 20 °C

2.2: 3.5 h / 0 - 50 °C

3.1: hydrogenchloride; isopentyl nitrite / methanol / 0.25 - 0.5 h / 0 °C

3.2: 20 °C / pH 9

4.1: acetonitrile / 1.5 h / Heating / reflux

With hydrogenchloride; sodium amide; isopentyl nitrite; In methanol; toluene; acetonitrile;

Reference yield:

: 1779-49-3
Methyltriphenylphosphonium bromide

: 1126475-32-8
{8-fluoro-1-[4-fluoro-3-(methoxycarbonyl)benzyl]-4-oxo-1,4-dihydrocinnolin-3-yl}(triphenyl)phosphonium bromide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium amide / toluene / 3 h / 20 °C

1.2: 3.5 h / 0 - 50 °C

2.1: hydrogenchloride; isopentyl nitrite / methanol / 0.25 - 0.5 h / 0 °C

2.2: 20 °C / pH 9

3.1: acetonitrile / 1.5 h / Heating / reflux

With hydrogenchloride; sodium amide; isopentyl nitrite; In methanol; toluene; acetonitrile;