2-hydroxy-4-((3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)(methyl)amino)benzaldehyde

Base Information

Chemical Name:2-hydroxy-4-((3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)(methyl)amino)benzaldehyde
CAS No.:1282550-81-5
Molecular Formula:C₁₇H₂₇N₃O₃
Molecular Weight:321.42
Hs Code.:

Synonyms:2-hydroxy-4-((3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)(methyl)amino)benzaldehyde

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Chemical Property of 2-hydroxy-4-((3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)(methyl)amino)benzaldehyde

Chemical Property:

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Technology Process of 2-hydroxy-4-((3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)(methyl)amino)benzaldehyde

There total 4 articles about 2-hydroxy-4-((3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)(methyl)amino)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 1282550-78-0
4-((3-chloropropyl)(methyl)amino)-2-hydroxybenzaldehyde

: 1282550-81-5
2-hydroxy-4-((3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)(methyl)amino)benzaldehyde

Guidance literature:: With potassium hydrogencarbonate; In acetonitrile; Reflux; Inert atmosphere;
DOI:10.1039/c0cc04113k

Reference yield:

: 1282550-75-7
3-((3-bromopropyl)(methyl)amino)phenol

: 1282550-81-5
2-hydroxy-4-((3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)(methyl)amino)benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 0.5 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: potassium hydrogencarbonate / acetonitrile / Reflux; Inert atmosphere

With potassium hydrogencarbonate; trichlorophosphate; In acetonitrile;
DOI:10.1039/c0cc04113k

Reference yield:

: 14318-66-2
3-methoxy-N-methylaniline

: 1282550-81-5
2-hydroxy-4-((3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)(methyl)amino)benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydrogencarbonate / acetonitrile / Reflux; Inert atmosphere

2.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

2.2: Cooling with ice; Inert atmosphere

3.1: trichlorophosphate / 0.5 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

3.3: Inert atmosphere

4.1: potassium hydrogencarbonate / acetonitrile / Reflux; Inert atmosphere

With boron tribromide; potassium hydrogencarbonate; trichlorophosphate; In dichloromethane; acetonitrile;
DOI:10.1039/c0cc04113k