N-(diphenyl-phosphinoylmethyl)-2,4,5-trimethoxy-N-methyl-benzamide

Base Information

• Chemical Name: N-(diphenyl-phosphinoylmethyl)-2,4,5-trimethoxy-N-methyl-benzamide
• CAS No.: 750649-54-8
• Molecular Formula: C₂₄H₂₆NO₅P
• Molecular Weight: 439.448
• Mol file: 750649-54-8.mol

Synonyms:N-(diphenyl-phosphinoylmethyl)-2,4,5-trimethoxy-N-methyl-benzamide

Chemical Property of N-(diphenyl-phosphinoylmethyl)-2,4,5-trimethoxy-N-methyl-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(diphenyl-phosphinoylmethyl)-2,4,5-trimethoxy-N-methyl-benzamide

There total 2 articles about N-(diphenyl-phosphinoylmethyl)-2,4,5-trimethoxy-N-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

asaronic acid (490-64-2) → N-(diphenyl-phosphinoylmethyl)-2,4,5-trimethoxy-N-methyl-benzamide (750649-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂; DMF / CH₂Cl₂

2: CH₂Cl₂

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1055/s-2004-829114

Reference yield:

2,4,5-trimethoxybenzoyl chloride (42833-66-9) + N-[(diphenylphosphinoyl)methyl]-N-methylamine (122365-23-5) → N-(diphenyl-phosphinoylmethyl)-2,4,5-trimethoxy-N-methyl-benzamide (750649-54-8)

Guidance literature:

In dichloromethane;

DOI:10.1055/s-2004-829114

Reference yield: 71.0%

N-(diphenyl-phosphinoylmethyl)-2,4,5-trimethoxy-N-methyl-benzamide (750649-54-8) → 3-(diphenyl-phosphinoyl)-5,6-dimethoxy-2-methyl-2,3-dihydro-isoindol-1-one (750649-59-3)

Guidance literature:

With 18-crown-6 ether; potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 - 20 ℃; for 2.25h;

DOI:10.1055/s-2004-829114

upstream raw materials:

2,4,5-trimethoxybenzoyl chloride

N-[(diphenylphosphinoyl)methyl]-N-methylamine

asaronic acid

Downstream raw materials:

3-(diphenyl-phosphinoyl)-5,6-dimethoxy-2-methyl-2,3-dihydro-isoindol-1-one