((2R,3R,4S,5R)-4-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate

Base Information

Chemical Name:((2R,3R,4S,5R)-4-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate
CAS No.:1434144-36-1
Molecular Formula:C₂₄H₂₁FN₂O₇
Molecular Weight:468.438
Hs Code.:

Synonyms:((2R,3R,4S,5R)-4-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate

Suppliers and Price of ((2R,3R,4S,5R)-4-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ((2R,3R,4S,5R)-4-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ((2R,3R,4S,5R)-4-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate

There total 6 articles about ((2R,3R,4S,5R)-4-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: ((2R,3R,4S)-5-acetoxy-4-(benzoyloxy)-3-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate

: 66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6
uracil

: 1434144-36-1
((2R,3R,4S,5R)-4-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: uracil; With N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile; for 0.5h; Reflux;

((2R,3R,4S)-5-acetoxy-4-(benzoyloxy)-3-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate; With tin(IV) chloride; In acetonitrile; at 20 ℃; for 12h; Reflux;

Reference yield:

: (3,4-dihydroxy-5-methoxytetrahydrofuran-2-yl)methyl benzoate

: 1434144-36-1
((2R,3R,4S,5R)-4-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 4 h / 0 °C

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 15 h / 20 °C

3.1: lithium chloride / tetrahydrofuran / 1 h / 40 °C

3.2: 3 h / -40 °C

4.1: pyridine; dmap / 15 h / 75 °C

5.1: sulfuric acid / water / 12 h / 20 °C / Cooling with ice

6.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 0.5 h / Reflux

6.2: 12 h / 20 °C / Reflux

With pyridine; dmap; N,O-bis-(trimethylsilyl)-acetamide; diethylamino-sulfur trifluoride; sulfuric acid; lithium chloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1434144-13-4
((2R,3R,5S)-3-fluoro-5-methoxy-4-oxotetrahydrofuran-2-yl)methyl benzoate

: 1434144-36-1
((2R,3R,4S,5R)-4-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium chloride / tetrahydrofuran / 1 h / 40 °C

1.2: 3 h / -40 °C

2.1: pyridine; dmap / 15 h / 75 °C

3.1: sulfuric acid / water / 12 h / 20 °C / Cooling with ice

4.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 0.5 h / Reflux

4.2: 12 h / 20 °C / Reflux

With pyridine; dmap; N,O-bis-(trimethylsilyl)-acetamide; sulfuric acid; lithium chloride; In tetrahydrofuran; water; acetonitrile;