((2R,3R,4S,5S)-4-(benzoyloxy)-3-fluoro-5-methoxy-4-methyltetrahydrofuran-2-yl)methyl benzoate

Base Information

Chemical Name:((2R,3R,4S,5S)-4-(benzoyloxy)-3-fluoro-5-methoxy-4-methyltetrahydrofuran-2-yl)methyl benzoate
CAS No.:1434144-16-7
Molecular Formula:C₂₁H₂₁FO₆
Molecular Weight:388.393
Hs Code.:

Synonyms:((2R,3R,4S,5S)-4-(benzoyloxy)-3-fluoro-5-methoxy-4-methyltetrahydrofuran-2-yl)methyl benzoate

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Chemical Property of ((2R,3R,4S,5S)-4-(benzoyloxy)-3-fluoro-5-methoxy-4-methyltetrahydrofuran-2-yl)methyl benzoate

Chemical Property:

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Technology Process of ((2R,3R,4S,5S)-4-(benzoyloxy)-3-fluoro-5-methoxy-4-methyltetrahydrofuran-2-yl)methyl benzoate

There total 4 articles about ((2R,3R,4S,5S)-4-(benzoyloxy)-3-fluoro-5-methoxy-4-methyltetrahydrofuran-2-yl)methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1434144-15-6
((2R,3R,4S,5S)-3-fluoro-4-hydroxy-5-methoxy-4-methyltetrahydrofuran-2-yl)methyl benzoate

: 98-88-4
benzoyl chloride

: 1434144-16-7
((2R,3R,4S,5S)-4-(benzoyloxy)-3-fluoro-5-methoxy-4-methyltetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: With pyridine; dmap; at 75 ℃; for 15h;

Reference yield:

: (3,4-dihydroxy-5-methoxytetrahydrofuran-2-yl)methyl benzoate

: 1434144-16-7
((2R,3R,4S,5S)-4-(benzoyloxy)-3-fluoro-5-methoxy-4-methyltetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 4 h / 0 °C

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 15 h / 20 °C

3.1: lithium chloride / tetrahydrofuran / 1 h / 40 °C

3.2: 3 h / -40 °C

4.1: pyridine; dmap / 15 h / 75 °C

With pyridine; dmap; diethylamino-sulfur trifluoride; lithium chloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1434144-13-4
((2R,3R,5S)-3-fluoro-5-methoxy-4-oxotetrahydrofuran-2-yl)methyl benzoate

: 1434144-16-7
((2R,3R,4S,5S)-4-(benzoyloxy)-3-fluoro-5-methoxy-4-methyltetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium chloride / tetrahydrofuran / 1 h / 40 °C

1.2: 3 h / -40 °C

2.1: pyridine; dmap / 15 h / 75 °C

With pyridine; dmap; lithium chloride; In tetrahydrofuran;