((2R,3S,4S,5S)-3-fluoro-4-hydroxy-5-methoxytetrahydrofuran-2-yl)methyl benzoate

Base Information

• Chemical Name: ((2R,3S,4S,5S)-3-fluoro-4-hydroxy-5-methoxytetrahydrofuran-2-yl)methyl benzoate
• CAS No.: 237410-13-8
• Molecular Formula: C₁₃H₁₅FO₅
• Molecular Weight: 270.258

Synonyms:((2R,3S,4S,5S)-3-fluoro-4-hydroxy-5-methoxytetrahydrofuran-2-yl)methyl benzoate

Chemical Property of ((2R,3S,4S,5S)-3-fluoro-4-hydroxy-5-methoxytetrahydrofuran-2-yl)methyl benzoate

Chemical Property:

Purity/Quality:

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Technology Process of ((2R,3S,4S,5S)-3-fluoro-4-hydroxy-5-methoxytetrahydrofuran-2-yl)methyl benzoate

There total 16 articles about ((2R,3S,4S,5S)-3-fluoro-4-hydroxy-5-methoxytetrahydrofuran-2-yl)methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

5-O-benzoate methyl α-D-xylofuranoside → methyl 5-O-benzoyl-2,3-dideoxy-2,3-difluoro-α-D-arabinofuranoside (237410-14-9) + ((2R,3S,4S,5S)-3-fluoro-4-hydroxy-5-methoxytetrahydrofuran-2-yl)methyl benzoate (237410-13-8)

Guidance literature:

With 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1080/15257779908041542

Reference yield: 29.0%

sodium benzoate (532-32-1) + Toluene-4-sulfonic acid (2S,3R,4R,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-fluoro-2-methoxy-tetrahydro-furan-3-yl ester (551929-57-8) → methyl 2,5-di-O-benzoyl-3-fluoro-3-deoxy-α-D-ribofuranoside (126716-27-6) + ((2R,3S,4S,5S)-3-fluoro-4-hydroxy-5-methoxytetrahydrofuran-2-yl)methyl benzoate (237410-13-8) + Benzoic acid (2R,3R,4R,5S)-3-fluoro-5-methoxy-4-(toluene-4-sulfonyloxy)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:

With 18-crown-6 ether; In dimethyl sulfoxide; Heating;

DOI:10.1081/NCN-120022701

Reference yield: 24.0%

(3,4-dihydroxy-5-methoxytetrahydrofuran-2-yl)methyl benzoate → 5-O-benzoyl-2-O-methyl-3-deoxy-3-fluoro-α-D-arabinofuranosyl fluoride + ((2R,3S,4S,5R)-3-fluoro-4-hydroxy-5-methoxytetrahydrofuran-2-yl)methyl benzoate (237410-10-5) + methyl 5-O-benzoyl-2,3-dideoxy-2,3-difluoro-α-D-arabinofuranoside (237410-14-9) + ((2R,3S,4S,5S)-3-fluoro-4-hydroxy-5-methoxytetrahydrofuran-2-yl)methyl benzoate (237410-13-8)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at 24 - 26 ℃; for 18h;

DOI:10.1016/j.tet.2019.02.027

upstream raw materials:

sodium benzoate

Toluene-4-sulfonic acid (2S,3R,4R,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-fluoro-2-methoxy-tetrahydro-furan-3-yl ester

methyl 3-fluoro-α-D-3-deoxy-arabinofuranoside

methyl 2,3-anhydro-α-D-lyxofuranoside

Downstream raw materials:

methyl 2,5-di-O-benzoyl-3-fluoro-3-deoxy-α-D-ribofuranoside

C₂₅H₂₁ClFN₅O₅

((2R,3R,4S,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-4-(benzoyloxy)-3-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate

((2R,3R,5S)-3-fluoro-5-methoxy-4-oxotetrahydrofuran-2-yl)methyl benzoate

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