7-(triethylsilyl)-10-(N,N-dimethylcarbamoyl)-14β-hydroxy-10-deacetylbaccatin III 1,14-carbonate

Base Information

Chemical Name:7-(triethylsilyl)-10-(N,N-dimethylcarbamoyl)-14β-hydroxy-10-deacetylbaccatin III 1,14-carbonate
CAS No.:186347-88-6
Molecular Formula:C₃₉H₅₃NO₁₃Si
Molecular Weight:771.934
Hs Code.:

Synonyms:7-(triethylsilyl)-10-(N,N-dimethylcarbamoyl)-14β-hydroxy-10-deacetylbaccatin III 1,14-carbonate

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Chemical Property of 7-(triethylsilyl)-10-(N,N-dimethylcarbamoyl)-14β-hydroxy-10-deacetylbaccatin III 1,14-carbonate

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Technology Process of 7-(triethylsilyl)-10-(N,N-dimethylcarbamoyl)-14β-hydroxy-10-deacetylbaccatin III 1,14-carbonate

There total 4 articles about 7-(triethylsilyl)-10-(N,N-dimethylcarbamoyl)-14β-hydroxy-10-deacetylbaccatin III 1,14-carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 994-30-9
triethylsilyl chloride

: 186347-88-6
7-(triethylsilyl)-10-(N,N-dimethylcarbamoyl)-14β-hydroxy-10-deacetylbaccatin III 1,14-carbonate

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / pyridine / dimethylformamide / 4 h / Ambient temperature

2: 80 percent / pyridine / CH₂Cl₂ / 0.17 h / 0 °C

3: 1.) LiHMDS / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, from -40 deg C to RT, 30 min

With pyridine; lithium hexamethyldisilazane; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960563e

Reference yield:

: 145533-34-2
14-β-hydroxy-10-deacetylbaccatin III

: 186347-88-6
7-(triethylsilyl)-10-(N,N-dimethylcarbamoyl)-14β-hydroxy-10-deacetylbaccatin III 1,14-carbonate

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / pyridine / dimethylformamide / 4 h / Ambient temperature

2: 80 percent / pyridine / CH₂Cl₂ / 0.17 h / 0 °C

3: 1.) LiHMDS / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, from -40 deg C to RT, 30 min

With pyridine; lithium hexamethyldisilazane; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960563e

Reference yield:

: 156965-59-2
7-(triethylsilyl)-14β-hydroxy-10-deacetylbaccatin III

: 186347-88-6
7-(triethylsilyl)-10-(N,N-dimethylcarbamoyl)-14β-hydroxy-10-deacetylbaccatin III 1,14-carbonate

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / pyridine / CH₂Cl₂ / 0.17 h / 0 °C

2: 1.) LiHMDS / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, from -40 deg C to RT, 30 min

With pyridine; lithium hexamethyldisilazane; In dichloromethane;
DOI:10.1021/jm960563e