TRANS-4-(CARBOBENZOXYAMINO)CYCLOHEXANECARBOXYLIC ACID

Base Information

• Chemical Name: TRANS-4-(CARBOBENZOXYAMINO)CYCLOHEXANECARBOXYLIC ACID
• CAS No.: 34771-04-5
• Molecular Formula: C15H19 N O4
• Molecular Weight: 277.32
• Hs Code.: 2924299090
• Mol file: 34771-04-5.mol

Synonyms:4-[N-(Carbobenzyloxy)amino]cyclohexanecarboxylicacid; trans-4-(Benzyloxycarbonylamino)cyclohexanecarboxylic acid

Chemical Property of TRANS-4-(CARBOBENZOXYAMINO)CYCLOHEXANECARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 3.32E-10mmHg at 25°C
• Melting Point: 217 °C
• Refractive Index: 1.565
• Boiling Point: 484.7°C at 760 mmHg
• PKA: 4.75±0.10(Predicted)
• Flash Point: 246.9°C
• PSA: 75.63000
• Density: 1.22g/cm³
• LogP: 2.94710
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Z-trans-4-aminocyclohexanecarboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TRANS-4-(CARBOBENZOXYAMINO)CYCLOHEXANECARBOXYLIC ACID

There total 6 articles about TRANS-4-(CARBOBENZOXYAMINO)CYCLOHEXANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-4-aminocyclohexanecarboxylic acid (1776-53-0,3685-23-2,3685-25-4,57043-03-5,66762-20-7) + phenyl chloroformate (1885-14-9) → (1r,4r)-4-(((benzyloxy)carbonyl)amino)cyclohexane carboxylic acid (34771-04-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 0 - 35 ℃; for 3h;

Reference yield:

trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid (15177-67-0) → (1r,4r)-4-(((benzyloxy)carbonyl)amino)cyclohexane carboxylic acid (34771-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 3.5 h / 110 °C

1.2: 6.16 h / 110 °C

2.1: sodium hydroxide; water / methanol / 3 h / 20 °C

With diphenyl phosphoryl azide; water; triethylamine; sodium hydroxide; In methanol; toluene;

Reference yield:

trans-hexahydroterephthalic acid (619-82-9) → (1r,4r)-4-(((benzyloxy)carbonyl)amino)cyclohexane carboxylic acid (34771-04-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2.1: barium(II) hydroxide / water; methanol / 24 h / 20 °C

3.1: triethylamine; diphenyl phosphoryl azide / toluene / 3.5 h / 110 °C

3.2: 6.16 h / 110 °C

4.1: sodium hydroxide; water / methanol / 3 h / 20 °C

With diphenyl phosphoryl azide; water; potassium carbonate; triethylamine; sodium hydroxide; barium(II) hydroxide; In methanol; water; N,N-dimethyl-formamide; toluene;

upstream raw materials:

trans-4-aminocyclohexanecarboxylic acid

phenyl chloroformate

trans-hexahydroterephthalic acid

dimethyl 1,4-cyclohexanedicarboxylate

Downstream raw materials:

trans-4-(benzyloxycarbonylamino)cyclohexanecarboxylic acid chloride

N-benzyloxycarbonyl-trans-4-(hydroxymethyl)cyclohexylamine

(1r,4r)-4-aminocyclohexanecarbonitrile

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