tert-butyl (3R)-4-(4-cyano-2-fluorobenzoyl)-3-methylpiperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl (3R)-4-(4-cyano-2-fluorobenzoyl)-3-methylpiperazine-1-carboxylate
CAS No.:1270982-29-0
Molecular Formula:C₁₈H₂₂FN₃O₃
Molecular Weight:347.389
Hs Code.:

Synonyms:tert-butyl (3R)-4-(4-cyano-2-fluorobenzoyl)-3-methylpiperazine-1-carboxylate

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Chemical Property of tert-butyl (3R)-4-(4-cyano-2-fluorobenzoyl)-3-methylpiperazine-1-carboxylate

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Technology Process of tert-butyl (3R)-4-(4-cyano-2-fluorobenzoyl)-3-methylpiperazine-1-carboxylate

There total 1 articles about tert-butyl (3R)-4-(4-cyano-2-fluorobenzoyl)-3-methylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 164149-28-4
4-cyano-2-fluorobenzoic acid

: 163765-44-4
(R)-tert-butyl 3-methylpiperazine-1-carboxylate

: 1270982-29-0
tert-butyl (3R)-4-(4-cyano-2-fluorobenzoyl)-3-methylpiperazine-1-carboxylate

Guidance literature:: 4-cyano-2-fluorobenzoic acid; With triethylamine; HATU; In tetrahydrofuran; for 0.25h;

(R)-tert-butyl 3-methylpiperazine-1-carboxylate; In tetrahydrofuran; for 3h;

Reference yield: 30.0%

: 42879-03-8
4-bromobut-2-enenitrile

: 1270982-29-0
tert-butyl (3R)-4-(4-cyano-2-fluorobenzoyl)-3-methylpiperazine-1-carboxylate

: 1270982-30-3
E/Z-4-({(2R)-4-[3-cyanoprop-2-en-1-yl]-2-methylpiperazin-1-yl}carbonyl)-3-fluorobenzonitrile

Guidance literature:: tert-butyl (3R)-4-(4-cyano-2-fluorobenzoyl)-3-methylpiperazine-1-carboxylate; With hydrogenchloride; In 1,4-dioxane; for 6.5h;

4-bromobut-2-enenitrile; With sodium hydrogencarbonate; In acetonitrile; for 24h;

Reference yield:

: 1270982-29-0
tert-butyl (3R)-4-(4-cyano-2-fluorobenzoyl)-3-methylpiperazine-1-carboxylate

: 1270980-84-1
4-[((2R)-4-{3-cyano-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propyl}-2-methylpiperazin-1-yl)carbonyl]-3-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane / 6.5 h

1.2: 24 h

2.1: potassium carbonate / N,N-dimethyl-formamide

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.2: 2 h

With hydrogenchloride; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;