Benzoic acid (2S,3S)-2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-butyl ester

Base Information

Chemical Name:Benzoic acid (2S,3S)-2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-butyl ester
CAS No.:194283-77-7
Molecular Formula:C₂₄H₃₄O₅Si
Molecular Weight:430.616
Hs Code.:

Synonyms:Benzoic acid (2S,3S)-2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-butyl ester

Suppliers and Price of Benzoic acid (2S,3S)-2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of Benzoic acid (2S,3S)-2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of Benzoic acid (2S,3S)-2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-butyl ester

There total 6 articles about Benzoic acid (2S,3S)-2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 194283-76-6
4-O-benzoyl-2-O-benzyl-L-threitol

: 194283-77-7
Benzoic acid (2S,3S)-2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-butyl ester

Guidance literature:: With 1H-imidazole; In dichloromethane; for 4h; Ambient temperature;
DOI:10.1021/jo9702812

Reference yield:

: 84379-53-3
2-O-benzyl-3,4-O-isopropylidene-L-threitol

: 194283-77-7
Benzoic acid (2S,3S)-2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature

2: 86 percent / PTSA / methanol; H₂O / Ambient temperature

3: 95 percent / imidazole / CH₂Cl₂ / 4 h / Ambient temperature

With pyridine; 1H-imidazole; toluene-4-sulfonic acid; In methanol; dichloromethane; water;
DOI:10.1021/jo9702812

Reference yield:

: 21154-16-5,35572-31-7,89015-57-6,141042-56-0
diethyl-2,3-O-benzylidene-D-tartrate

: 194283-77-7
Benzoic acid (2S,3S)-2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / LiAlH₄ / diethyl ether; CH₂Cl₂ / 1.) room temperature, 1 h, 2.) reflux, 4 h

2: 70 percent / PTSA, MS 4A / CH₂Cl₂ / 7 h / Heating

3: 95 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature

4: 86 percent / PTSA / methanol; H₂O / Ambient temperature

5: 95 percent / imidazole / CH₂Cl₂ / 4 h / Ambient temperature

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; toluene-4-sulfonic acid; In methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/jo9702812