3-methyl-3-((3-(trifluoromethyl)phenyl)thio)butanoic acid

Base Information

• Chemical Name: 3-methyl-3-((3-(trifluoromethyl)phenyl)thio)butanoic acid
• CAS No.: 1276662-82-8
• Molecular Formula: C₁₂H₁₃F₃O₂S
• Molecular Weight: 278.295
• Mol file: 1276662-82-8.mol

Synonyms:3-methyl-3-((3-(trifluoromethyl)phenyl)thio)butanoic acid

Chemical Property of 3-methyl-3-((3-(trifluoromethyl)phenyl)thio)butanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methyl-3-((3-(trifluoromethyl)phenyl)thio)butanoic acid

There total 1 articles about 3-methyl-3-((3-(trifluoromethyl)phenyl)thio)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.6%

3-Methylbutenoic acid (541-47-9) + 3-trifluoromethyl-thiophenol (937-00-8) → 3-methyl-3-((3-(trifluoromethyl)phenyl)thio)butanoic acid (1276662-82-8)

Guidance literature:

With iodine; at 105 ℃; for 3h; Inert atmosphere;

Reference yield: 56.0%

3-methyl-3-((3-(trifluoromethyl)phenyl)thio)butanoic acid (1276662-82-8) → 3-methyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butanoic acid (1276662-86-2)

Guidance literature:

With Oxone; In methanol; water; at 20 ℃; for 16h;

Reference yield:

3-methyl-3-((3-(trifluoromethyl)phenyl)thio)butanoic acid (1276662-82-8) → 3-methyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butan-1-amine (1276663-01-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: Oxone / water; methanol / 16 h / 20 °C

2.1: acetyl chloride / 2 h / 0 °C / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

5.1: triethylamine; sodium azide / acetonitrile / 16 h / Reflux

6.1: hydrogen / palladium(II) hydroxide / ethanol / 1 h / 2585.81 Torr

With Oxone; lithium aluminium tetrahydride; sodium azide; hydrogen; triethylamine; acetyl chloride; palladium(II) hydroxide; In tetrahydrofuran; methanol; ethanol; water; acetonitrile;

upstream raw materials:

3-Methylbutenoic acid

3-trifluoromethyl-thiophenol

Downstream raw materials:

3-methyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butyl methanesulfonate

1-((4-azido-2-methylbutan-2-yl)sulfonyl)-3-(trifluoromethyl)benzene

3-methyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butan-1-amine

tert-butyl (3-methyl-3-(3-(trifluoromethyl)phenylsulfonyl)butyl)carbamate