tert-butyl (3-methyl-3-(3-(trifluoromethyl)phenylsulfonyl)butyl)carbamate

Base Information

• Chemical Name: tert-butyl (3-methyl-3-(3-(trifluoromethyl)phenylsulfonyl)butyl)carbamate
• CAS No.: 1276663-02-5
• Molecular Formula: C₁₇H₂₄F₃NO₄S
• Molecular Weight: 395.443
• Mol file: 1276663-02-5.mol

Synonyms:tert-butyl (3-methyl-3-(3-(trifluoromethyl)phenylsulfonyl)butyl)carbamate

Chemical Property of tert-butyl (3-methyl-3-(3-(trifluoromethyl)phenylsulfonyl)butyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (3-methyl-3-(3-(trifluoromethyl)phenylsulfonyl)butyl)carbamate

There total 9 articles about tert-butyl (3-methyl-3-(3-(trifluoromethyl)phenylsulfonyl)butyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-methyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butan-1-amine (1276663-01-4) → tert-butyl (3-methyl-3-(3-(trifluoromethyl)phenylsulfonyl)butyl)carbamate (1276663-02-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

3-Methylbutenoic acid (541-47-9) → tert-butyl (3-methyl-3-(3-(trifluoromethyl)phenylsulfonyl)butyl)carbamate (1276663-02-5)

Guidance literature:

Multi-step reaction with 8 steps

1.1: iodine / 3 h / 105 °C / Inert atmosphere

2.1: Oxone / water; methanol / 16 h / 20 °C

3.1: acetyl chloride / 2 h / 0 °C / Reflux

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

6.1: triethylamine; sodium azide / acetonitrile / 16 h / Reflux

7.1: hydrogen / palladium(II) hydroxide / ethanol / 1 h / 2585.81 Torr

8.1: triethylamine / dichloromethane / 1 h / 20 °C

With Oxone; lithium aluminium tetrahydride; sodium azide; hydrogen; iodine; triethylamine; acetyl chloride; palladium(II) hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

3-trifluoromethyl-thiophenol (937-00-8) → tert-butyl (3-methyl-3-(3-(trifluoromethyl)phenylsulfonyl)butyl)carbamate (1276663-02-5)

Guidance literature:

Multi-step reaction with 8 steps

1.1: iodine / 3 h / 105 °C / Inert atmosphere

2.1: Oxone / water; methanol / 16 h / 20 °C

3.1: acetyl chloride / 2 h / 0 °C / Reflux

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

6.1: triethylamine; sodium azide / acetonitrile / 16 h / Reflux

7.1: hydrogen / palladium(II) hydroxide / ethanol / 1 h / 2585.81 Torr

8.1: triethylamine / dichloromethane / 1 h / 20 °C

With Oxone; lithium aluminium tetrahydride; sodium azide; hydrogen; iodine; triethylamine; acetyl chloride; palladium(II) hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile;

upstream raw materials:

di-tert-butyl dicarbonate

3-methyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butan-1-amine

3-Methylbutenoic acid

3-trifluoromethyl-thiophenol

Downstream raw materials:

tert-butyl methyl(3-methyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butyl)carbamate

N,3-dimethyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butan-1-amine hydrochloride