C₁₇H₁₉FN₄O₂

Base Information

• Chemical Name: C₁₇H₁₉FN₄O₂
• CAS No.: 1301740-80-6
• Molecular Formula: C₁₇H₁₉FN₄O₂
• Molecular Weight: 330.362
• Mol file: 1301740-80-6.mol

Synonyms:C₁₇H₁₉FN₄O₂

Chemical Property of C₁₇H₁₉FN₄O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₉FN₄O₂

There total 4 articles about C₁₇H₁₉FN₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-3-methoxypyridine (52605-96-6) + (S)-4-(5-amino-2-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-oxazin-2-amine (1301740-78-2) → C17H19FN4O2 (1301740-80-6)

Guidance literature:

With sulfuric acid; In isopropyl alcohol; for 40h; Reflux;

Reference yield:

(S)-3-amino-3-(2-fluoro-5-nitrophenyl)butan-1-ol hydrochloride (1301740-70-4) → C17H19FN4O2 (1301740-80-6)

Guidance literature:

Multi-step reaction with 5 steps

1: water; acetone / 2 h / 20 °C

2: methyl iodide; N-ethyl-N,N-diisopropylamine / acetonitrile / 34 h / 20 - 40 °C

3: sulfuric acid / 1.5 h / 80 °C

4: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 20 h

5: sulfuric acid / isopropyl alcohol / 40 h / Reflux

With sulfuric acid; hydrogen; N-ethyl-N,N-diisopropylamine; methyl iodide; palladium 10% on activated carbon; In tetrahydrofuran; water; isopropyl alcohol; acetone; acetonitrile;

Reference yield:

C18H18FN3O4S (1301740-75-9) → C17H19FN4O2 (1301740-80-6)

Guidance literature:

Multi-step reaction with 4 steps

1: methyl iodide; N-ethyl-N,N-diisopropylamine / acetonitrile / 34 h / 20 - 40 °C

2: sulfuric acid / 1.5 h / 80 °C

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 20 h

4: sulfuric acid / isopropyl alcohol / 40 h / Reflux

With sulfuric acid; hydrogen; N-ethyl-N,N-diisopropylamine; methyl iodide; palladium 10% on activated carbon; In tetrahydrofuran; isopropyl alcohol; acetonitrile;

upstream raw materials:

2-chloro-3-methoxypyridine

(S)-4-(5-amino-2-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-oxazin-2-amine

(S)-3-amino-3-(2-fluoro-5-nitrophenyl)butan-1-ol hydrochloride

C₁₈H₁₈FN₃O₄S