1301740-70-4Relevant academic research and scientific papers
Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial
Koriyama, Yuji,Hori, Akihiro,Ito, Hisanori,Yonezawa, Shuji,Baba, Yoshiyasu,Tanimoto, Norihiko,Ueno, Tatsuhiko,Yamamoto, Shiho,Yamamoto, Takahiko,Asada, Naoya,Morimoto, Kenji,Einaru, Shunsuke,Sakai, Katsunori,Kanazu, Takushi,Matsuda, Akihiro,Yamaguchi, Yoshitaka,Oguma, Takuya,Timmers, Maarten,Tritsmans, Luc,Kusakabe, Ken-Ichi,Kato, Akira,Sakaguchi, Gaku
, p. 1873 - 1888 (2021)
Accumulation of amyloid β peptides (Aβ) is thought to be one of the causal factors of Alzheimer's disease (AD). The aspartyl protease β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting protease for Aβ production, and therefore
