2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid {3-[4-(2-benzyloxycarbonyl-ethyl)-phenoxy]-phenyl}-cyano-methyl ester

Base Information

Chemical Name:2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid {3-[4-(2-benzyloxycarbonyl-ethyl)-phenoxy]-phenyl}-cyano-methyl ester
CAS No.:208251-90-5
Molecular Formula:C₃₂H₃₃NO₅
Molecular Weight:511.618
Hs Code.:

Synonyms:2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid {3-[4-(2-benzyloxycarbonyl-ethyl)-phenoxy]-phenyl}-cyano-methyl ester

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Chemical Property of 2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid {3-[4-(2-benzyloxycarbonyl-ethyl)-phenoxy]-phenyl}-cyano-methyl ester

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Technology Process of 2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid {3-[4-(2-benzyloxycarbonyl-ethyl)-phenoxy]-phenyl}-cyano-methyl ester

There total 8 articles about 2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid {3-[4-(2-benzyloxycarbonyl-ethyl)-phenoxy]-phenyl}-cyano-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31770-76-0
3-(4-hydroxyphenyl)propionic acid benzyl ester

: 208251-90-5
2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid {3-[4-(2-benzyloxycarbonyl-ethyl)-phenoxy]-phenyl}-cyano-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) t-BuOK, 2.) CuCl, Cu, pyridine, 18-crown-6 / 1.) xylene, heating, 2.) xylene, reflux, 17 h

2: aq. H₂SO₄, SiO₂ / CH₂Cl₂ / 2 h

3: aq. HCl / tetrahydrofuran / 0.5 h

4: pyridine / CH₂Cl₂ / 0.5 h / 0 - 20 °C

With pyridine; hydrogenchloride; 18-crown-6 ether; sulfuric acid; potassium tert-butylate; silica gel; copper; copper(l) chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jf9710847

Reference yield:

: 24303-61-5
2,2,3,3-tetramethylcyclopropanecarbonyl chloride

: benzyl 3-{4-[3-(cyanohydroxymethyl)phenoxy]phenyl}propanoate

: 208251-90-5
2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid {3-[4-(2-benzyloxycarbonyl-ethyl)-phenoxy]-phenyl}-cyano-methyl ester

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 0.5h; Yield given;
DOI:10.1021/jf9710847

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 208251-90-5
2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid {3-[4-(2-benzyloxycarbonyl-ethyl)-phenoxy]-phenyl}-cyano-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / H₂SO₄ / methanol / 3 h / Ambient temperature

2: 1.) t-BuOK, 2.) CuCl, Cu, pyridine, 18-crown-6 / 1.) xylene, heating, 2.) xylene, reflux, 17 h

3: aq. H₂SO₄, SiO₂ / CH₂Cl₂ / 2 h

4: aq. HCl / tetrahydrofuran / 0.5 h

5: pyridine / CH₂Cl₂ / 0.5 h / 0 - 20 °C

With pyridine; hydrogenchloride; 18-crown-6 ether; sulfuric acid; potassium tert-butylate; silica gel; copper; copper(l) chloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jf9710847